文献类型：期刊文献

英文题名：Folate-functionalized nanoparticles for controlled 5-Fluorouracil delivery

作者：Zhang, Yan[1];Li, Jiashi[1];Lang, Meidong[1];Tang, Xiaolin[2];Li, Lei[2];Shen, Xizhong[2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Shanghai Key Lab Adv Polymer Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Fudan Univ, Zhongshan Hosp, Dept Digest, Shanghai 200032, Peoples R China

年份：2011

卷号：354

期号：1

起止页码：202

外文期刊名：JOURNAL OF COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20105113501375);WOS:【SCI-EXPANDED(收录号:WOS:000286121700029)】；

基金：Financial support from the Fundamental Research Funds for the Central Universities, the National Natural Science Foundation of China (20804015), Specialized Research Fund for the Doctoral Program of Higher Education (200802511021), the Natural Science Foundation of Shanghai (08ZR1406000), Shanghai Key Laboratory Project (08DZ2230500) and Program for Changjiang Scholars and Innovative Research Team in University (IRT0825) are gratefully acknowledged.

语种：英文

外文关键词：Poly(epsilon-caprolactone-co-4-maleate-epsilon-caprolactone); Nanoparticles; Folate; 5-Fluorouracil; Anti-tumor effect

摘要：In this paper, folate conjugated poly(epsilon-caprolactone-co-4-maleate-epsilon-caprolactone) (P(CL-co-MCL)-folate) was prepared by a carbodiimide coupling reaction, i.e., the vitamin folic acid (FA) was covalently linked to the main chain of the maleate-functionalized polymer, poly(epsilon-caprolactone-co-4-maleate-epsilon-caprolactone) (P(CL-co-MCL)). Then the 5-Fluorouracil (5-FU) loaded nanoparticles of P(CL-co-MCL)-folate were achieved by solvent-evaporation method. Their properties were extensively studied by dynamic light scattering (DLS) and scan electron microscopy (SEM). DLS and SEM showed that the nanoparticles were in a well-defined spherical shape with a uniform size distribution. We also investigated the entrapment and in vitro release behavior, which indicated that the release speed of 5-FU could be well controlled and the release half-life period could reach 16.86 h, which was 26.4 times longer than that of pure 5-FU. The in vitro targeting test displayed that the 5-FU loaded P(CL-co-MCL)-folate nanoparticles exhibited an enhanced cell inhibition because folate targeting increased the concentration of 5-FU loaded P(CL-co-MCL)-folate nanoparticles in the tumor cells with folate receptor overexpressed. Meanwhile, the tumor inhibition of 5-FU loaded P(CL-co-MCL)-folate nanoparticles was much higher than that of pure 5-FU and that of 5-FU loaded P(CL-co-MCL) nanoparticles. Therefore, P(CL-co-MCL)-folate nanoparticles would be highly beneficial for biomedical and pharmaceutical applications. (C) 2010 Elsevier Inc. All rights reserved.