文献类型：期刊文献

英文题名：One-pot solventless preparation of PEGylated black phosphorus nanoparticles for photoacoustic imaging and photothermal therapy of cancer

作者：Sun, Caixia[1,2];Wen, Ling[2];Zeng, Jianfeng[2];Wang, Yong[2];Sun, Qiao[2];Deng, Lijuan[1];Zhao, Chongjun[1];Li, Zhen[2]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai Key Lab Adv Polymer Mat, Key Lab Ultrafine Mat,Minist Educ, Shanghai 200237, Peoples R China;[2]Soochow Univ, Collaborat Innovat Ctr Radiat Med, Sch Radiol & Interdisciplinary Sci RAD X, Ctr Mol Imaging & Nucl Med,Jiangsu Higher Educ In, Suzhou 215123, Peoples R China

年份：2016

卷号：91

起止页码：81

外文期刊名：BIOMATERIALS

收录：;EI(收录号：20161302155471);WOS:【SCI-EXPANDED(收录号:WOS:000374611900007)】；

基金：This work was supported by the National Natural Science Foundation of China (81471657, 81527901, 20504026), Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD), Shanghai Natural Science Foundation (No. 13ZR1411900), the Shanghai Leading Academic Discipline Project (B502), the Shanghai Key Laboratory Project (08DZ2230500). Z. Li acknowledges the support from the program of Jiangsu Specially Appointed Professorship. The authors would like to thank Dr. Tania Silver for critical reading of the manuscript.

语种：英文

外文关键词：Black phosphorus; PEGylated nanoparticles; Photoacoustic imaging; Photothermal therapy

摘要：Black phosphorus (BP) nanostructures such as nanosheets and nanoparticles have attracted considerable attention in recent years due to their unique properties and great potential in various physical, chemical, and biological fields. In this article, water-soluble and biocompatible PEGylated BP nanoparticles with a high yield were prepared by one-pot solventless high energy mechanical milling technique. The resultant BP nanoparticles can efficiently convert near infrared (NIR) light into heat, and exhibit excellent photostability, which makes them suitable as a novel nanotheranostic agent for photoacoustic (PA) imaging and photothermal therapy of cancer. The in-vitro results demonstrate the excellent biocompatibility of PEGylated BP nanoparticles, which can be used for photothermal ablation of cancer cells under irradiation with NIR light. The in-vivo PA images demonstrate that these BP nanoparticles can be efficiently accumulated in tumors through the enhanced permeability retention effect The resultant BP nano particles can be further utilized for photothermal ablation of tumors by irradiation with NIR light The tumor-bearing mice were completely recovered after photothermal treatment with BP nanoparticles, in comparison with mice from control groups. Our research highlights the great potential of PEGylated BP nanoparticles in detection and treatment of cancer. (c) 2016 Elsevier Ltd. All rights reserved.