文献类型：期刊文献

英文题名：Electrochemical one-pot cascade synthesis of thio(seleno)cyanato-substituted thiazolidine-2-imines without external electrolyte

作者：Yu, Xiao[1,2];Hao, Liqiang[1,2];Liu, Xian[1,2];Jin, Shengkui[1,2];Li, Yangchen[1,2];Liu, Yiping[3];Ji, Yafei[1,2]

机构：[1]East China Univ Sci & Technol, Engn Res Ctr Pharmaceut Proc Chem, Minist Educ, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai, Peoples R China;[3]Chongqing Med & Pharmaceut Coll, Sch Pharm, Chongqing, Peoples R China

年份：2024

卷号：22

期号：48

起止页码：9366

外文期刊名：ORGANIC & BIOMOLECULAR CHEMISTRY

收录：;EI(收录号：20244517340677);WOS:【SCI-EXPANDED(收录号:WOS:001347457600001)，CCR-EXPANDED(收录号:WOS:001347457600001)】；

语种：英文

外文关键词：Synthesis (chemical) - Synthetic metals

摘要：A novel synthetic method has been developed for generating thio(seleno)cyanato-substituted thiazolidine-2-imines via an electrochemical one-pot cascade reaction. This reaction employs isothiocyanates, N-2-en-1-amines, and KSCN (or KSeCN) under mild conditions, obviating the need for metals, chemical oxidants, and external electrolytes. The protocol is effective with unactivated alkenes and facilitates the synthesis of five- and six-membered thio(seleno)cyanato-substituted thiazolidine-2-imines. The versatility is demonstrated by its straightforward operation and scalability to gram-scale production, underscoring its potential for broader application.