文献类型：期刊文献

英文题名：Four previously undescribed diketopiperazines from marine fungus Aspergillus puniceus FAHY0085 and their effects on liver X receptor a

作者：Hong, Qi[1];Guo, Miao-Miao[3];Yang, Jin[1];Wei, Xing[1];Liao, Li[4,5];Xin, Xiu-Juan[1];Zhang, Di[1,2];An, Fa-Liang[1,6]

机构：[1]East China Univ Sci & Technol, Shanghai Collaborat Innovat Ctr Biomfg, Sch Biotechnol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]Jiangsu Ocean Univ, Jiangsu Inst Marine Resources Dev, Sch Pharm, Lianyungang 222005, Peoples R China;[3]Beijing Technol & Business Univ, Key Lab Cosmet, China Natl Light Ind, 11-33 Fucheng Rd, Beijing 100048, Peoples R China;[4]Minist Nat Resources, Polar Res Inst China, Key Lab Polar Sci, Shanghai 200136, Peoples R China;[5]Shanghai Jiao Tong Univ, Sch Oceanog, Shanghai 200240, Peoples R China;[6]Marine Biomed Sci & Technol Innovat Platform Lin g, 4 Lane 218, Haiji Sixth Rd, Shanghai 201306, Peoples R China

年份：2023

卷号：214

外文期刊名：PHYTOCHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001068733500001)】；

基金：This work was funded by the National Natural Science Foundation of China (Nos. 41876189, 81703388) , and the National Key R & amp; D Program of China (Nos. 2018YFC1706206, 2019YFC0312504) . This work was also supported by the Open Research Fund Program of State Key Laboratory of Bioreactor Engineering, Shanghai Collaborative Innovation Center for Biomanufacturing, School of Biotechnology and Key Laboratory of Cosmetic (Beijing Technology and Business University) , China National Light Industry (KLC-2022-YB3) .

语种：英文

外文关键词：Marine -derived fungus; Diketopiperazines; LXR & alpha;

摘要：Four previously undescribed diketopiperazine-type alkaloids including one oxepin-containing diketopiperazinetype alkaloid, oxepinamide L (1), three 4-quinazolinone alkaloids, puniceloids E-G (10-12), together with 12 known analogues, protuboxepin D (2), oxepinamides D-G, J-K and I (3-9), puniceloids B-D (13-15) and protubonine B (16), were isolated from the culture of the marine-derived fungus Aspergillus puniceus FAHY0085. The structures of the previously undescribed compounds were comprehensively elucidated by detailed interpretation of their NMR and HRESIMS data. Their absolute configurations were unambiguously determined by ROESY experiments, Marfey's method, calculated ECD experiments and single-crystal X-ray difraction analysis. Compounds (3-4, 6-8, 14-15) were evaluated for their cytotoxic activity against HepG2, MCF-7, SW1116 and HeLa cells and compound 6 and 14 showed moderate cytotoxic activity against HeLa cells with IC50 49.61 +/- 2.91 and 28.38 +/- 1.57 mu M, respectively. Compounds (1-8, 11-15) were screened for their transcriptional activation of liver X receptor a and compound 11 with known compounds 13-15 showed significant transcriptional activation of liver X receptor a with EC50 values in the range 2-50 mu M.