文献类型：期刊文献

英文题名：Palladium-Catalyzed Transfer Hydrogenation and Acetylation of N -Heteroarenes with Sodium Hydride as the Reductant

作者：Luo, Fan[1,2]; Chen, Xiaobei[1]; Yu, Jing[2]; Yin, Yuejia[2]; Hu, Xiaoxiao[2]; Hu, Ying[3]; Liu, Xuejun[4]; Chen, Xiaodong[4]; Zhang, Shilei[2]; Hu, Yanwei[2]

机构：[1] Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioengineering Reactor, School of Pharmacy, East China University of Science & Technology, Shanghai, 200237, China; [2] Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, 199 Ren'ai Road, Jiangsu, Suzhou, 215123, China; [3] Department of Pharmacy, Suzhou Vocational Health College, 28 Kehua Road, Suzhou, 215009, China; [4] Shanghai Neutan Pharmaceutical Co. Ltd., Building 26, No. 555 Huanqiao Road, Pudong New Area, Shanghai, 201315, China

年份：2022

卷号：55

期号：9

起止页码：1451

外文期刊名：Synthesis (Germany)

收录：EI(收录号：20225213306206)

语种：英文

外文关键词：Catalysis - Hydrides - Hydrogenation - Palladium compounds - Sodium compounds

摘要：An efficient and convenient palladium-catalyzed reductive system by employing sodium hydride as the hydrogen donor and acetic anhydride as an activator has been developed for transfer hydrogenation and acetylation of a wide range of N-heteroarenes including quinoline, phthalazine, quinoxaline, phenazine, phenanthridine, and indole. Moreover, acridine substrates could be directly reduced without the use of acetic anhydride. This protocol provides a simple method for the preparation of various saturated N-heterocycles. ? 2023. Thieme. All rights reserved.