文献类型：期刊文献

英文题名：A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo [a,c]phenazine for detection of superoxide anions and its application in cell imaging

作者：Yang, Ji[1];Liu, Xianglong[1];Wang, Honglei[2,3];Tan, Haoqi[2,3];Xie, Xiaoxu[1];Zhang, Xiao[1];Liu, Chenchen;Qu, Xue[2,3];Hua, Jianli[1]

机构：[1]East China Univ Sci & Technol, Inst Fine Chem, Coll Chem & Mol Engn, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China

年份：2018

卷号：143

期号：5

起止页码：1242

外文期刊名：ANALYST

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000426704200026)】；

基金：This work was supported by the NSFC/China (21421004, 21372082, 21572062, 21772040 and 51573047), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017).

语种：英文

摘要：A new turn-on near-infrared fluorescence probe (BDP) based on dibenzo[a, c] phenazine for superoxide anion detection with aggregation-induced emission properties as well as a desirable large Stokes shift was designed and synthesized. After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with nearinfrared emission. The fluorescent sensor BDP has a high selectivity for superoxide anions over some other intracellular ROSs, reductants, metal ions and amino acids. When HepG2 cells undergo apoptosis and inflammation, BDP is a good probe to keep track of the endogenous superoxide anion level by confocal laser scanning microscopic imaging.