文献类型：期刊文献

英文题名：Organocatalytic enantioselective Michael addition reactions of fluoromalonates with α,β-unsaturated aldehydes

作者：Li Hao[1];Ji YaFei[2];Li Jian[2];Zhang ShiLei[1];Yu ChenGuang[1];Wang Wei[1,2]

机构：[1]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA;[2]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut Sci, Shanghai 200237, Peoples R China

年份：2010

卷号：53

期号：1

起止页码：135

外文期刊名：SCIENCE CHINA-CHEMISTRY

收录：;EI(收录号：20100712710766);WOS:【SCI-EXPANDED(收录号:WOS:000276547200017)】；

基金：Financial support for this work provided by the NSF (CHE-0704015) is gratefully acknowledged. Thanks are expressed to Dr. Elieen N. Duesler for performing X-ray analysis. The Bruker X8 X-ray diffractometer was purchased via an NSF CRIF: MU award to the University of New Mexico, CHE-0443580.

语种：英文

外文关键词：organocatalysis; alpha,beta-unsaturated aldehydes; chiral fluorinated compounds; Michael addition

摘要：A new organocatalytic enantioselective Michael addition of alpha-fluoromalonate to enals has been developed. The process is efficiently catalyzed by readily available chiral diphenylpyrolinol TES ether under mild reaction conditions to afford versatile highly enantioenriched fluorinated aldehydes.