文献类型：期刊文献

英文题名：High-yield porphyrin production through metabolic engineering and biocatalysis (05 Jun, 10.1038/s41587-024-02267-3, 2024)

作者：Chen, Haihong[1,2];Wang, Yaohong[1,2];Wang, Weishan[3];Cao, Ting[1,2];Zhang, Lu[1,2];Wang, Zhengduo[1,2];Chi, Xuran[1,2];Shi, Tong[1,2];Wang, Huangwei[1,2];He, Xinwei[1,2];Liang, Mindong[1,2];Yang, Mengxue[1,2];Jiang, Wenyi[1,2];Lv, Dongyuan[1,2];Yu, Jiaming[1,2];Zhu, Guoliang[1,2];Xie, Yongtao[1,2];Gao, Bei[1,2];Wang, Xinye[1,2];Liu, Xueting[1,2];Li, Youyuan[1,2];Ouyang, Liming[1,2];Zhang, Jingyu[1,2];Liu, Huimin[1,2];Li, Zilong[3];Tong, Yaojun[4];Xia, Xuekui[5];Tan, Gao-Yi[1,2];Zhang, Lixin[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Sch Biotechnol, Shanghai, Peoples R China;[3]Chinese Acad Sci, State Key Lab Microbial Resources, Inst Microbiol, Beijing, Peoples R China;[4]Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, Shanghai, Peoples R China;[5]Qilu Univ Technol, Biol Inst, Shandong Acad Sci, Key Biosensor Lab Shandong Prov, Jinan, Peoples R China

年份：2025

卷号：43

期号：10

起止页码：1729

外文期刊名：NATURE BIOTECHNOLOGY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001261215900004)】；

基金：We thank Q. Chen (School of Biotechnology, East China University of Science and Technology), L. Zhang (School of Chemistry and Molecular Engineering, East China Normal University) and W. Zhang (State Key Laboratory of Microbial Technology, Shandong University) for their technical support in enzyme mining, engineering and characterization. We are also deeply grateful to Z. Zhou (Institute of Plant Physiology and Ecology, Chinese Academy of Sciences) for her generous gift of the ZX-5 strain and to Inner Mongolia Kingdomway Pharmaceutical Co., Ltd. for providing the HY01 strain. We would like to extend our gratitude to D.-Q. Lin from the College of Chemical and Biological Engineering at Zhejiang University for his invaluable guidance in conducting the techno-economic analysis and for providing assistance in using the SuperPro Designer simulation software. During the manuscript preparation, we also greatly appreciate the constructive insights provided by J.-J. Zhong, L. Bai and T. Liu from the School of Life Sciences and Biotechnology, Shanghai Jiao Tong University. This work was financially supported, in part, by grants from the National Key Research and Development Program of China (2020YFA0907800 to Z.L. and 2020YFA0907304 to T.G.-Y.); the National Natural Science Foundation of China (32121005 to Z.L. and 32370064 and 31870040 to T.G.-Y.); 2023 Double World-Class Project-Key Program-Intelligent Biomanufacturing to Z.L.; and the Open Funding Project of the State Key Laboratory of Microbial Metabolism (MMLKF22-03 to T.G.-Y.).

语种：英文