文献类型：期刊文献

中文题名：复配相转移催化体系催化的芳香化合物卤素交换氟化反应

英文题名：Halogen-Exchange Fluoridation Reaction of Aromatic Compounds Catalyzed by the Compatibility of Phase Transfer Catalysts

作者：朱含[1];罗晓燕[1]

机构：[1]华东理工大学药学院,上海200237

年份：2017

卷号：43

期号：2

起止页码：203

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;Scopus;北大核心:【北大核心2014】；CSCD:【CSCD_E2017_2018】；

基金：国家自然科学基金(21372074)

语种：中文

中文关键词：卤素交换氟化反应;相转移催化剂;四苯基溴化膦;18-冠-6

外文关键词：halogen-exchange fluoridation reaction; phase transfer catalyst; tetraphenylphosphonium bromide; 18-crown-6

摘要：卤素交换氟化反应是制备芳香氟化物的重要方法,在工业生产中得到了广泛的应用。以四苯基溴化膦(x=5%)和18-冠-6/(x=1%)为复配相转移催化剂,成功实现了单卤素或多卤素取代的芳香化合物氟化反应,收率最高可达92%。该方法具有催化剂用量低、底物范围较宽等优点。
The halogen-exchange fluoridation reaction is an important approach to prepare aromatic fluorides,which has been widely applied in industrial production. The fluoridation reactions of single or multiple halogen substituted aromatic compounds were carried out with the complex phase transfer catalyst,Ph4PBr/（x = 5%） and 18-crown-6/（x = 1 %）, affording the corresponding products in up to 92% yield. This method has the advantages such as low amount of catalyst and wide substrate scope.