文献类型：期刊文献

英文题名：Cholesterol-Modified Black Phosphorus Nanospheres for the First NIR-II Fluorescence Bioimaging

作者：Xu, Yifan[1,2];Ren, Feng[2];Liu, Hanghang[2];Zhang, Hao[2];Han, Yaobao[2];Liu, Zheng[2];Wang, Wenliang[2];Sun, Qiao[2];Zhao, Chongjun[1];Li, Zhen[2]

机构：[1]East China Univ Sci & Technol, Sch Mat Sci & Engn, Key Lab Ultrafine Mat, Minist Educ,Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China;[2]Soochow Univ, Sch Radiol & Interdisciplinary Sci RAD X, Collaborat Innovat Ctr Radiat Med,Jiangsu Higher, Ctr Mol Imaging & Nucl Med,State Key Lab Radiat M, Suzhou 215123, Peoples R China

年份：2019

卷号：11

期号：24

起止页码：21399

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20192407044146);WOS:【SCI-EXPANDED(收录号:WOS:000472683300013)】；

基金：Z.L. acknowledges support from the National Key Research and Development Program of China (2018YFA0208800), National Natural Science Foundation of China (81471657, 81527901), the 1000 Plan for Young Talents, Jiangsu Specially Appointed Professorship, and the Program of Jiangsu Innovative and Entrepreneurial Talents. The authors also are grateful for support from the Jiangsu Provincial Key Laboratory of Radiation Medicine and Protection, the Priority Academic Development Program of Jiangsu Higher Education Institutions (PAPD).

语种：英文

外文关键词：black phosphorus; cholesterol modification; nanospheres; NIR-II fluorescence; bioimaging

摘要：Black phosphorus (BP) nanostructures with unique layer-dependent properties have been extensively applied in the fields of electronic devices, energy conversion and storage, and nanomedicine. As a narrow band gap semiconductor, they are expected to show strong second near-infrared (NIR-II) fluorescence. However, there is no report on the NIR-II fluorescence of free-standing BP nanostructures, which have great potential in the NIR-II fluorescence bioimaging because of their excellent biocompatibility and biodegradability. Here, for the first time, we report that the BP nanoparticles modified with cholesterol exhibit strong NIR-II fluorescence and can be encapsulated with the PEGylated lipid to form BP@lipid-PEG nanospheres for in vitro and in vivo NIR-II imaging. The resultant BP@lipid-PEG nanospheres exhibit broad emissions from 900 to 1650 nm under excitation by an 808 nm laser and have 8% quantum yield of that of standard dye IR-26. We also show that the NIR-II fluorescence image acquired with emission beyond 1400 nm has the sharpest contrast and can be used to in situ measure the diameter of blood vessels. In addition to NIR-II fluorescence imaging, we also show the potential of BP@lipid-PEG nanospheres in photoacoustic (PA) imaging. Both the long-wavelength NIR-II fluorescence imaging and PA imaging reveal that the as-fabricated BP@lipid-PEG nanospheres can be gradually metabolized by the liver in 48 h, thus making them promising for bioapplications.