文献类型：期刊文献

英文题名：Bright, Stable, and Biocompatible Organic Fluorophores Absorbing/Emitting in the Deep Near-Infrared Spectral Region

作者：Lei, Zuhai[2];Li, Xinran[2];Luo, Xiao[2];He, Haihong[2];Zheng, Jing[3];Qian, Xuhong[1,2];Yang, Youjun[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200236, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab Chem Biol, Meilong Rd 130, Shanghai 200236, Peoples R China;[3]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, Meilong Rd 130, Shanghai 200236, Peoples R China

年份：2017

卷号：56

期号：11

起止页码：2979

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20170603325322);WOS:【SCI-EXPANDED(收录号:WOS:000397307600027)】；

基金：The work is supported by the Fundamental Research Funds for the Central Universities (Nos. WY1514053 and WY1516017) and the National Natural Science Foundation of China (Nos. 21372080, 21572061, and 21236002).

语种：英文

外文关键词：fluorophores; imaging; near-infrared

摘要：Small-molecule organic fluorophores spectrally active in the 800-950 nm region are sought-after for their broad potential in biomedical and material applications. We have developed a new family of brightly fluorescent dyes (ECX) to meet this challenge. ECX dyes are transparent to the visible region, while strongly absorbing in the NIR region at approximately 880 nm. They emit at around 915 nm with a fluorescence quantum yield up to 13.3%. ECX dyes exhibit high chemostability, high photostability, and low tendency to aggregate. Other merits of ECX dyes include low degree of solvatochromism and facile post-synthetic derivatization. ECX dyes potentially make available the 800-950 nm region for spectroscopic and microscopic applications and are also expected to find broad material applications.