文献类型：期刊文献

英文题名：Fluorescent Probes Based on AIEgen-Mediated Polyelectrolyte Assemblies for Manipulating Intramolecular Motion and Magnetic Relaxivity

作者：Yao, Yongkang[1,2];Ding, Peng[3,4];Yan, Chenxu[1,2];Tao, Yining[1,2];Peng, Bo[5];Liu, Weimin[5];Wang, Junyou[3,4];Stuart, Martien A. Cohen A.[3,4];Guo, Zhiqian[1,2]

机构：[1]East China Univ Sci & Technol, Dept Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]East China Univ Sci, Inst Fine Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[4]East China Univ Sci & Technol Shanghai, Shanghai Key Lab Multiphase Mat Chem Engn, Shanghai 200237, Peoples R China;[5]Shanghai Tech Univ Shanghai, Sch Phys Sci & Technol, Shanghai 200237, Peoples R China

年份：2023

卷号：62

期号：13

外文期刊名：ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

收录：;EI(收录号：20230613569929);WOS:【SCI-EXPANDED(收录号:WOS:000931473700001)】；

基金：This work was supported by National Key Research and Development Program (2021YFA0910000), NSFC/China (22225805, 21878087, and 21908060), Innovation Program of Shanghai Municipal Education Commission, Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28), Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), Shanghai Science and Technology Committee Rising-Star Program (22QC1400400), Programme of Introducing Talents of Discipline to Universities (B16017). This study was performed in strict accordance with the NIH guidelines for the care and use of laboratory animals (NIH Publication No. 85-23 Rev. 1985).

语种：英文

外文关键词：Aggregation-Induced-Emission; Excited-State Intramolecular Motion; Fluorescent Probe; Magnetic Relaxivity; Polyelectrolyte

摘要：Uniting photothermal therapy (PTT) with magnetic resonance imaging (MRI) holds great potential in nanotheranostics. However, the extensively utilized hydrophobicity-driven assembling strategy not only restricts the intramolecular motion-induced PTT, but also blocks the interactions between MR agents and water. Herein, we report an aggregation-induced emission luminogen (AIEgen)-mediated polyelectrolyte nanoassemblies (APN) strategy, which bestows a unique "soft" inner microenvironment with good water permeability. Femtosecond transient spectra verify that APN well activates intramolecular motion from the twisted intramolecular charge transfer process. This de novo APN strategy uniting synergistically three factors (rotational motion, local motion, and hydration number) brings out high MR relaxivity. For the first time, APN strategy has successfully modulated both intramolecular motion and magnetic relaxivity, achieving fluorescence lifetime imaging of tumor spheroids and spatio-temporal MRI-guided high-efficient PTT.