文献类型：期刊文献

英文题名：Palladium-catalyzed direct mono -aroylation of O -arylmethyl and aryl-substituted acetoxime ethers

作者：Shao, Ling-Yan[1]; Xu, Zhi[1]; Wang, Cun-Ying[2]; Fu, Xiao-Pan[1]; Chen, Miao-Miao[1]; Liu, Hong-Wei[1]; Ji, Ya-Fei[1]

机构：[1] School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China; [2] School of Chemical Engineering and Technology, Xuzhou College of Industrial Technology, Xuzhou, 221006, China

年份：2018

卷号：16

期号：34

起止页码：6284

外文期刊名：Organic and Biomolecular Chemistry

收录：EI(收录号：20183605783792)

语种：英文

外文关键词：Catalysis - Organometallics - Ketones - Palladium

摘要：An efficient palladium-catalyzed ortho-aroylation of O-arylmethyl and aryl-substituted acetoxime ethers has been developed; this method has high mono-site selectivity and does not require exogenous ligands. Under the direction of a simple exo-acetoxime auxiliary, a broad scope of masked arylmethyl alcohols and phenols as well as various aromatic aldehydes are compatible with this transformation, which probably follows a mechanistic pathway involving a six- or five-membered exo-cyclopalladated intermediate. The strategy can be expediently adopted to prepare synthetically valuable 1H-benzo[d][1,2]oxazines and benzo[d]isoxazoles. The directing group can be easily removed from the products to afford the functionalized diaryl ketones. ? 2018 The Royal Society of Chemistry.