文献类型：期刊文献

英文题名：Propionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene saponin from Centella asiatica

作者：Shen, Xueqing[1];Guo, Miaomiao[1];Yu, Haiyuan[1];Liu, Dan[2];Lu, Zhi[2];Lu, Yanhua[1]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]Shanghai Inoherb Co Ltd, Technol Ctr, Shanghai, Peoples R China

年份：2019

卷号：83

期号：3

起止页码：561

外文期刊名：BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

收录：;EI(收录号：20191006592870);WOS:【SCI-EXPANDED(收录号:WOS:000458668300020)】；

基金：This work was supported by the Industry-University-Institute collaboration of Baoshan District Committee of Science and Technology (No. 17-C-1) and the Fundamental Research Funds for the Central Universities (No. 22221818014).

语种：英文

外文关键词：Madecassoside; skin hydration; hyaluronan; Propionibacterium acnes; anti-inflammation

摘要：Madecassoside is a major pentacyclic triterpene saponin from Centella asiatica with multiple pharmaceutical activities. In this study, we focused on its Propionibacterium acnes related anti-inflammation and skin hydration activities, both of which play important roles in skin homeostasis and barrier function. Madecassoside significantly inhibited the pro-inflammatory cytokine IL-1 beta, TLR2 and nuclear translocation of NF-kappa B in P. acnes stimulated THP-1 human monocytic cells. In addition, madecasssoside exhibited significant effects on enhancement of skin hydration through increasing the key moisturizing contributors of aquaporin-3, loricrin and involucrin in HaCaT keratinocytes as well as hyaluronan (HA) secretion in human dermal fibroblasts. The upregulation of HA synthases (HAS1, HAS2, HAS3) and inhibition to ROS formation accounted for the increment of HA content. Together, the in vitro study implied the potential medical and cosmetic application of madecassoside in skin protection.