文献类型：期刊文献

英文题名：Synthesis of novel imidazole-based triheterocycles via a domino Ugi/Michael reaction and silver-catalyzed heteroannulation

作者：Li, Zhenghua[1];Zhao, Yaping[1,2];Tian, Guilong[1];He, Yi[1];Song, Gonghua[1,2];Van Meervelt, Luc[3];Van der Eycken, Erik V.[1]

机构：[1]Univ Leuven KU Leuven, LOMAC, Celestijnenlaan 200F, B-3001 Leuven, Belgium;[2]East China Univ Sci & Technol, Shanghai Key Lab Chem Biol, Shanghai 200237, Peoples R China;[3]Katholieke Univ Leuven, Dept Chem, Biomol Architecture, Celestijnenlaan 200F, B-3001 Leuven, Belgium

年份：2016

卷号：6

期号：105

起止页码：103601

外文期刊名：RSC ADVANCES

收录：;EI(收录号：20164603000485);WOS:【SCI-EXPANDED(收录号:WOS:000387726500095)】；

基金：The authors wish to thank the FWO [Fund for Scientific Research-Flanders (Belgium)] and the Research Fund of the University of Leuven (KU Leuven) for financial support. LVM thank the Hercules Foundation for supporting the purchase of the diffractometer through project AKUL/09/0035. ZL, YZ, GT and YH appreciate the China Scholarship Council (CSC) for providing the financial support in their doctoral studies.

语种：英文

外文关键词：Microwave irradiation - Catalysis

摘要：An efficient and diversity-oriented synthetic strategy for novel triheterocyclic imidazo-pyrrolo-pyrazine/diazepine/diazocine derivatives is elaborated. The process utilizes a domino four-component Ugi reaction/Michael reaction of imidazole-2-carbaldehyde, propargyl amines, 2-alkynoic acids and isonitriles to deliver functionalized imidazole-pyrrolones, which upon a silver-catalyzed heteroannulation in aqueous medium under microwave irradiation furnishes the desired triheterocycles in good to excellent yields.