文献类型：期刊文献

英文题名：Ruthenium Complex-Catalyzed Domino Addition/exo-Cycloisomerization of Propargylic Alcohols and Tosyl Isocyanate to Form Oxazolidinones

作者：Li, Deng Yuan[1];Chen, Hao Jie[1];Liu, Pei Nian[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat & Inst Fine Chem, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：357

期号：6

起止页码：1193

外文期刊名：ADVANCED SYNTHESIS & CATALYSIS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000352712500013)，CCR-EXPANDED(收录号:WOS:000352712500013)】；

基金：This work was supported by the National Natural Science Foundation of China (Project Nos. 21172069, 21372072 and 21190033), the Science Fund for Creative Research Groups (21421004), NCET (NCET-13-0798), the Basic Research Program of the Shanghai Committee of Sci. & Tech. (Project No. 13M1400802) and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：addition; cycloisomerization; domino reactions; oxazolidinone; ruthenium

摘要：A ruthenium complex with a tetradentate nitrogen-phosphorus mixed ligand is shown to be an efficient catalyst for domino addition/exo-cycloisomerization of propargylic alcohols and tosyl isocyanate. In the presence of 2-5 mol% ruthenium complex, a range of terminal propargylic alcohols were reacted with tosyl isocyanate to furnish the corresponding oxazolidinone product exclusively in moderate to excellent yields. Mechanistic studies suggest that propargylic alcohol and tosyl isocyanate undergo addition firstly to generate propargylic carbamate, which is then activated by the ruthenium complex to form an eta(2)-alkyne complex, rather than the ruthenium vinylidene intermediate, to afford the final oxazolidinone product.