文献类型：期刊文献

英文题名：Advances in structural design of lipid-based nanoparticle carriers for delivery of macromolecular drugs, phytochemicals and anti-tumor agents

作者：Angelova, Angelina[1];Garamus, Vasil M.[2];Angelov, Borislav[3];Tian, Zhenfen[4,5];Li, Yawen[4,5];Zou, Aihua[4,5]

机构：[1]Univ Paris Saclay, Univ Paris Sud, CNRS UMR 8612, Inst Gallen Paris Sud,LabEx LERMIT, F-92290 Chatenay Malabry, France;[2]Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany;[3]Acad Sci Czech Republ, Inst Phys, ELI Beamlines, Na Slovance 2, CZ-18221 Prague, Czech Republic;[4]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Sch Chem & Mol Engn, Inst Appl Chem, Shanghai 200237, Peoples R China

年份：2017

卷号：249

起止页码：331

外文期刊名：ADVANCES IN COLLOID AND INTERFACE SCIENCE

收录：;EI(收录号：20171803636642);WOS:【SCI-EXPANDED(收录号:WOS:000418316500022)】；

基金：We gratefully acknowledge the support by Shanghai Natural Science Foundation (Grant No. 15ZR1409900), the National Natural Science Foundation of China (Grant No. 21573070), Fundamental Research Funds for the Central Universities. We thank the staff of the BL19U2 beamline at the National Cencer for Protein Science Shanghai and Shanghai Synchrotron Radiation Facility (Shanghai, People's Republic of China). B.A. is supported by the project ELI - Extreme Light Infrastructure - phase 2 (CZ.02.1.01/0.0/0.0/15_008/0000162) and ELIBIO (CZ.02.1.01/0.0/0.0/15_003/0000447) from European Regional Development Fund, and the Czech Science Foundation Grant GACR 17-00973S. We also acknowledge the allocation of beam time at the Synchrotron Radiation Facility DESY (Deutsche Elektronen Synchrotron, Hamburg, Germany) - storage ring PETRA III, BioSAXS beamline P12 of the European Molecular Biology Laboratory (EMBL).

语种：英文

外文关键词：Liquid crystalline nanocarriers; Drug delivery; BioSAXS; Nanostructured lipid carriers; Nanomedicines; Self-assembled biomaterials

摘要：The present work highlights recent achievements in development of nanostructured dispersions and biocolloids for drug delivery applications. We emphasize the key role of biological small-angle X-ray scattering (BioSAXS) investigations for the nanomedicine design. A focus is given on controlled encapsulation of small molecular weight phytochemical drugs in lipid-based nanocarriers as well as on encapsulation of macromolecular siRNA, plasmid DNA, peptide and protein pharmaceuticals in nanostructured nanoparticles that may provide efficient intracellular delivery and triggered drug release. Selected examples of utilisation of the BioSAXS method for characterization of various types of liquid crystalline nanoorganizations (liposome, spongosome, cubosome, hexosome, and nanostructured lipid carriers) are discussed in view of the successful encapsulation and protection of phytochemicals and therapeutic biomolecules in the hydrophobic or the hydrophilic compartments of the nanocarriers. We conclude that the structural design of the nanoparticulate carriers is of crucial importance for the therapeutic outcome and the triggered drug release from biocolloids.