文献类型：期刊文献

英文题名：Cobalt-Catalyzed Asymmetric Reductive Propargylic Addition of α-Ketimino Esters

作者：Liu, Ning[1];Yu, Zhiying[1];Zhao, Wenyu[1];Wu, Xianqing[1];Qu, Jingping[1];Chen, Yifeng[1];Zhu, Wei-Hong[1]

机构：[1]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn,Key Lab Adv Mat & Joint Int Re, Shanghai 200237, Peoples R China

年份：2026

卷号：91

期号：7

起止页码：2791

外文期刊名：JOURNAL OF ORGANIC CHEMISTRY

收录：;EI(收录号：20260820146849);WOS:【SCI-EXPANDED(收录号:WOS:001684120300001)】；

基金：This work was supported by the Key Project of Science and Technology Innovation 2030 (no. 2023ZD0121001), the National Natural Science Foundation of China (22171079, 22371071, 92356301, 22401092, and 22571081), the Science and Technology Commission of Shanghai Municipality (grant no. 24DX1400200), the Program of Introducing Talents of Discipline to Universities (B16017), the Shanghai Sailing Program (23YF1408800), and the Fundamental Research Funds for the Central Universities. The authors thank the Analysis and Testing Center of East China University of Science and Technology for help with NMR and HRMS analysis. The authors also thank Yinhui Wu's exceptional contributions to the experimental part.

语种：英文

外文关键词：Addition reactions - Amines - Carbon - Carbonyl compounds - Cobalt - Enantioselectivity - Methyl ester - Scaffolds

摘要：The Nozaki-Hiyama-Kishi (NHK) reaction serves as a powerful method for stereoselective carbon-carbon bond formation under mild conditions. While significant progress has been made in the enantioselective propargylation of carbonyl compounds, its application to imines remains underdeveloped. Herein, we report a catalytic asymmetric reductive propargylic addition to alpha-ketimino esters, providing direct access to chiral propargylated amines with high chemoselectivity and enantioselectivity. This method expands the synthetic utility of NHK-type reactions toward nitrogen-containing scaffolds, offering a complementary route to enantioenriched amine derivatives under mild and efficient conditions.