文献类型：期刊文献

英文题名：Nickel-Catalyzed Regioselective Hydroarylation of Internal Enamides

作者：Wang, Chenchen[1,2];Xi, Yang[1,2];Huang, Wenyi[1,2];Qu, Jingping[1,2];Chen, Yifeng[1,2]

机构：[1]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Key Lab Adv Mat,Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Feringa Nobel Prize Scientist Joint Res Ctr, Joint Int Res Lab Precis Chem & Mol Engn,Sch Chem, Shanghai 200237, Peoples R China

年份：2020

卷号：22

期号：23

起止页码：9319

外文期刊名：ORGANIC LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000598141000034)，CCR-EXPANDED(收录号:WOS:000598141000034)】；

基金：This work was supported by the National Natural Science Foundation of China (21702060), the Shanghai Municipal Science and Technology Major Project (Grant 2018SHZDZX03), the Program of Introducing Talents of Discipline to Universities (B16017), and the Fundamental Research Funds for the Central Universities. The authors thank the Research Center of Analysis and Test of East China University of Science and Technology for help with NMR analysis.

语种：英文

摘要：Herein, we disclose a nickel-catalyzed three-component reaction of internal enamide, diethoxymethylsilane, and aryl iodide to provide expedient access to benzylic amide derivatives. The protocol features a broad substrate scope with a moderate to excellent isolated yield under the mild condition. The high regioselectivity of Ni-catalyzed enamide hydroarylation can be attributed to the directing effect by the prefunctionalized nitrogen-containing group on the alkenes.