文献类型：期刊文献

英文题名：Core-Shell-Corona Silica Hybrid Nanoparticles Templated by Spherical Polyelectrolyte Brushes: A Study by Small Angle X-ray Scattering

作者：Han, Haoya[1,2];Li, Li[1];Wang, Weihua[3];Tian, Yuchuan[1];Wang, Yunwei[1];Wang, Junyou[1];von Klitzing, Regine[2];Guo, Xuhong[1,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]Tech Univ Darmstadt, Dept Phys, Alarich Weiss Str 10, D-64287 Darmstadt, Germany;[3]Sinopec Shanghai Res Inst Petrochem Technol, Shanghai 201208, Peoples R China;[4]Shihezi Univ, Engn Res Ctr Mat Chem Engn Xinjiang Bingtuan, Xinjiang 832000, Peoples R China

年份：2017

卷号：33

期号：38

起止页码：9857

外文期刊名：LANGMUIR

收录：;EI(收录号：20174004223206);WOS:【SCI-EXPANDED(收录号:WOS:000411918500038)】；

语种：英文

外文关键词：Dynamic light scattering - Shells (structures) - High resolution transmission electron microscopy - Ionic strength - Polyelectrolytes - Drug delivery - Silica nanoparticles

摘要：Core-shell-corona silica/polymer hybrid nanoparticles with narrow size distribution were prepared in the template of spherical polyelectrolyte brushes (SPB) which consist of a solid polystyrene (PS) core densely grafted with linear poly(acrylic acid) (PAA) chains. The microstructure of obtained hybrid nanoparticles was studied by small-angle X-ray scattering (SAXS) and in combination with dynamic light scattering (DLS) and transmission electron microscopy (TEM). The generation of silica shell within the brush is confirmed by the significant increase of the electron density in the shell, and the silica shell showed a unique inner-loose outer -dense structure, whose thickness is pH sensitive but is insensitive to ionic strength as revealed by fitting SAXS data. After dissolving the PS core, hollow silica nanoparticles were obtained and determined by SAXS, which should be ideal carriers for pH-triggered drug delivery. SAXS is confirmed to be a powerful method to characterize the core shell corona silica/polymer hybrid and hollow silica nanoparticles.