文献类型：期刊文献

英文题名：Self-assembled stable sponge-type nanocarries for Brucea javanica oil delivery

作者：Zou, Aihua[1,2,10];Li, Yawen[1,2];Chen, Yiyin[1,2];Angelova, Angelina[3];Garamus, Vasil M.[4];Li, Na[5,6];Drechsler, Markus[7];Angelov, Borislav[8];Gong, Yabin[9]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Inst Appl Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[3]Univ Paris Sud, Univ Paris Saclay, CNRS, UMR 8612,Inst Galien Paris Sud,LabEX LERMIT, F-92296 Chatenay Malabry, France;[4]Helmholtz Zentrum Geesthacht, Ctr Mat & Coastal Res, D-21502 Geesthacht, Germany;[5]Natl Ctr Prot Sci Shanghai, Shanghai 200237, Peoples R China;[6]Shanghai Inst Biochem & Cell Biol, Shanghai 200237, Peoples R China;[7]Univ Bayreuth, Bayreuth Inst Macromol Res BIMF, Lab Soft Matter Electron Microscopy, D-95440 Bayreuth, Germany;[8]Acad Sci Czech Republ, ELI Beamlines, Inst Phys, Slovance 1999-2, CZ-18221 Prague, Czech Republic;[9]Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Shanghai 200437, Peoples R China;[10]East China Univ Sci & Technol, Shanghai, Peoples R China

年份：2017

卷号：153

起止页码：310

外文期刊名：COLLOIDS AND SURFACES B-BIOINTERFACES

收录：;EI(收录号：20171003427073);WOS:【SCI-EXPANDED(收录号:WOS:000400211100037)】；

基金：We gratefully acknowledge the support of this work by Shanghai Natural Science Foundation (Grant No. 15ZR1409900), the National Natural Science Foundation of China (Grant No. 21573070), Fundamental Research Funds for the Central Universities, National Natural Science Foundation of China (Grant No. 31200617) and Knowledge Innovation Program of CAS (Grant No. 2013KIP103). We thank the staff of the BL19U2 beamline at the National Center for Protein Science Shanghai and Shanghai Synchrotron Radiation Facility (Shanghai, People's Republic of China) for assistance during data collection. B.A. was supported by the project ELI - Extreme Light Infrastructure - phase 2 (CZ.02.1.01/0.0/0.0/15_008/0000162) from European Regional Development Fund.

语种：英文

外文关键词：Nanosponges; Liquid crystalline nanocarriers; Self-assembly; Phytochemical anticancer nanomedicines

摘要：Sponge-type nanocarriers (spongosomes) are produced upon dispersion of a liquid crystalline sponge phase formed by self-assembly of an amphiphilic lipid in excess aqueous phase. The inner organization of the spongosomes is built-up by randomly ordered bicontinuous lipid membranes and their surfaces are stabilized by alginate chains providing stealth properties and colloidal stability. The present study elaborates spongosomes for improved encapsulation of Brucea javanica oil (BJO), a traditional Chinese medicine that may strongly inhibit proliferation and metastasis of various cancers. The inner structural organization and the morphology characteristics of BJO-loaded nanocarriers at varying quantities of BJO were determined by cryogenic transmission electron microscopy (Cryo-TEM), small angle X-ray scattering (SAXS) and dynamic light scattering (DLS). Additionally, the drug loading and drug release profiles for BJO-loaded spongosome systems also were determined. We found that the sponge-type liquid crystalline lipid membrane organization provides encapsulation efficiency rate of BJO as high as 90%. In vitro cytotoxicity and apoptosis study of BJO spongosome nanoparticles with A549 cells demonstrated enhanced anti-tumor efficiency. These results suggest potential clinical applications of the obtained safe spongosome formulations. (C) 2017 Elsevier B.V. All rights reserved.