文献类型：期刊文献

英文题名：The chronic toxicity of bisphenol A to Caenorhabditis elegans after long-term exposure at environmentally relevant concentrations

作者：Zhou, Dong[1];Yang, Jie[2];Li, Hui[1];Cui, Changzheng[1];Yu, Yunjiang[3];Liu, Yongdi[1];Lin, Kuangfei[1]

机构：[1]E China Univ Sci & Technol, State Environm Protect Key Lab Environm Risk Asse, State Key Lab Bioreactor Engn, Sch Resources & Environm Engn, Shanghai 200237, Peoples R China;[2]Shanghai Acad Environm Sci, Res Inst Wastes & Soil Remediat, Shanghai 200233, Peoples R China;[3]South China Inst Environm Sci, Ctr Environm Hlth Res, MEP, Guangzhou 510535, Guangdong, Peoples R China

年份：2016

卷号：154

起止页码：546

外文期刊名：CHEMOSPHERE

收录：;EI(收录号：20161602250472);WOS:【SCI-EXPANDED(收录号:WOS:000376693700068)】；

基金：The wild-type nematode strain used in this study was provided by the CGC, which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). This work was also financially supported by the National Environmental Protection Public Welfare Science and Technology Research Program of China (No. 201309047), National Natural Science Foundation of China (51578240, 51378208, 41273109), Program for New Century Excellent Talents in University (NCET-13-0797), Innovation Program of Shanghai Municipal Education Commission (14ZZ059), Fok Ying Tung Education Foundation (141077) and Fundamental Research Funds for the Central Universities (222201313008, 222201516015), Innovation Program of Shanghai municipal of Science and Technology Commission (15DZ1205804).

语种：英文

外文关键词：Caenorhabditis elegans; Bisphenol A; Long-term exposure; Ecotoxicological evaluation; Environmental risks

摘要：To investigate biological effects of bisphenol A (BPA) over the long term, the model animal Caenorhabditis elegans was used to conduct the chronic exposure. C. elegans were exposed to BPA (0.0001-10 mu M) from L4 larvae to day-10 adult in the present chronic toxicity assay system. Multiple endpoints at the physiological (growth, locomotion behaviors and lifespan), biochemical (lipofuscin accumulation), molecular (stress-related genes expressions), and population (population size) levels were examined. At the physiological level, BPA exposure induced significant negative effects on the indicators. Among the endpoints, head thrash was most sensitive and the detection limit was 0.001 mu M. At the biochemical level, BPA exposure induced no significant effects on lipofuscin accumulation. At the molecular level, BPA induced strong stress responses in vivo. At the population level, the population size was significantly decreased in the treatment groups from 0.1 to 10 mu M. Compared to the previous short-term toxicity evaluation, long-term exposure to BPA induced a more obvious response at the same concentration, and the phenomenon might be due to cumulative toxic effects. By the Pearson correlation analyses, cep-1 was speculated to act as an important role in BPA-induced chronic toxicity on C. elegans. (C) 2016 Elsevier Ltd. All rights reserved.