文献类型：期刊文献

英文题名：Monitoring Dopamine Quinone-Induced Dopaminergic Neurotoxicity Using Dopamine Functionalized Quantum Dots

作者：Ma, Wei;Liu, Hui-Ting;Long, Yi-Tao[1]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China; E China Univ Sci & Technol, Inst Fine Chem, Shanghai 200237, Peoples R China

年份：2015

卷号：7

期号：26

起止页码：14352

外文期刊名：ACS APPLIED MATERIALS & INTERFACES

收录：;EI(收录号：20152801025512);WOS:【SCI-EXPANDED(收录号:WOS:000357963700021)】；

基金：This research was supported by the 973 Program (2014CB748500 and 2013CB733700), the National Natural Science Foundation of China (21125522, 21305045, 21327807), and the Fundamental Research Funds for the Central Universities (WJ1313004).

语种：英文

外文关键词：dopaminergic neurotoxicity; quantum dots; dopamine quinone; cysteine residue; fluorescence

摘要：Dopamine (DA) quinone-induced dopaminergic neurotoxicity is known to occur due to the interaction between DA quinone and cysteine (Cys) residue, and it may play an important a role in pathological processes associated with neurodegeneration. RI this study, we monitored the interaction process of DA to form DA quinone and the subsequent Cys residue using dopamine functionalized quantum dots (QDs). The fluorescence (FL) of the QD bioconjugates changes as a function of the structure transformation during the interaction process, providing a potential FL tool for monitoring dopaminergic neurotoxicity.