文献类型：期刊文献

英文题名：3D Bioprinting of the Sustained Drug Release Wound Dressing with Double-Crosslinked Hyaluronic-Acid-Based Hydrogels

作者：Si, Haopeng[1];Xing, Tianlong[2];Ding, Yulong[1];Zhang, Hongbo[1];Yin, Ruixue[1];Zhang, Wenjun[3,4]

机构：[1]East China Univ Sci & Technol, Sch Mech & Power Engn, Shanghai 200237, Peoples R China;[2]Black Flame Biomed LtD, Shanghai 201318, Peoples R China;[3]Shanghai Univ, Sch Mechatron & Automat, Shanghai 200444, Peoples R China;[4]Univ Saskatchewan, Div Biomed Engn, Saskatoon, SK S7N 5C9, Canada

年份：2019

卷号：11

期号：10

外文期刊名：POLYMERS

收录：;EI(收录号：20194207558185);WOS:【SCI-EXPANDED(收录号:WOS:000495382700053)】；

基金：The authors gratefully acknowledge the financial support of The Shanghai Science and Technology Innovation Program (19441909600) and The Opening project of Shanghai Key Laboratory of Orthopedic Implant (KFKT2019001).

语种：英文

外文关键词：3D bioprinting; hyaluronic acid; double-crosslinked; biodegradable; wound dressing

摘要：Hyaluronic acid (HA)-based hydrogels are widely used in biomedical applications due to their excellent biocompatibility. HA can be Ultraviolet (UV)-crosslinked by modification with methacrylic anhydride (HA-MA) and crosslinked by modification with 3,3 '-dithiobis(propionylhydrazide) (DTP) (HA-SH) via click reaction. In the study presented in this paper, a 3D-bioprinted, double-crosslinked, hyaluronic-acid-based hydrogel for wound dressing was proposed. The hydrogel was produced by mixing HA-MA and HA-SH at different weight ratios. The rheological test showed that the storage modulus (G') of the HA-SH/HA-MA hydrogel increased with the increase in the HA-MA content. The hydrogel had a high swelling ratio and a high controlled degradation rate. The in vitro degradation test showed that the hydrogel at the HA-SH/HA-MA ratio of 9:1 (S9M1) degraded by 89.91% +/- 2.26% at 11 days. The rheological performance, drug release profile and the cytocompatibility of HA-SH/HA-MA hydrogels with loaded Nafcillin, which is an antibacterial drug, were evaluated. The wound dressing function of this hydrogel was evaluated by Live/Dead staining and CCK-8 assays. The foregoing results imply that the proposed HA-SH/HA-MA hydrogel has promise in wound repair applications.