文献类型：期刊文献

英文题名：Self-assembly and disassembly of a redox-responsive ferrocene-containing amphiphilic block copolymer for controlled release

作者：Liu, Lichao[1];Rui, Leilei[1];Gao, Yun[1];Zhang, Weian[1]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab Adv Polymer Mat, Shanghai 200237, Peoples R China

年份：2015

卷号：6

期号：10

起止页码：1817

外文期刊名：POLYMER CHEMISTRY

收录：;EI(收录号：20151000602446);WOS:【SCI-EXPANDED(收录号:WOS:000350641400016)】；

基金：This work was financially supported by the National Natural Science Foundation of China (no. 21074035 and 51173044), Research Innovation Program of SMEC (no. 14ZZ065), Shanghai Pujiang Program under 14PJ1402600 and the Project-sponsored by SRF for ROCS, SEM. W. Z. also acknowledges the support from the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：Controlled drug delivery - Manganese compounds - Targeted drug delivery - Iron compounds - Polyethylene glycols - Polyethylene oxides - Carboxylation - Self assembly - Solutions - Block copolymers - High resolution transmission electron microscopy - Organometallics - Potash

摘要：Stimuli-responsive block copolymer micelles have recently emerged as promising drug delivery systems with controllable drug release. Herein, we report well-defined redox-responsive ferrocene-containing amphiphilic block copolymers PEG-b-PMAEFc, which were synthesized by the atom transfer radical polymerization (ATRP) of 2-(methacryloyloxy) ethyl ferrocene-carboxylate (MAEFc) using a PEG-based macro-ATRP agent. These block copolymers can self-assemble into various interesting nanostructures in aqueous solution. The self-assembled morphology of amphiphilic block copolymers is influenced by the nature of the common solvents used, the polymer composition and concentration, and the addition of beta-cyclodextrin (beta-CD) and redox agents (H2O2 and KMnO4), the effects of which were investigated by transmission electron microscopy (TEM) and dynamic light scattering (DLS). Furthermore, the redox agent H2O2 can be used to trigger the release of encapsulated cargo (Rhodamine B) in the polymeric nanocarriers. This redox behavior of the amphiphiles could open up an approach for redox-controlled drug delivery systems.