文献类型：期刊文献

中文题名：固相萃取结合气相色谱-串联质谱测定卷烟中3种禁用香料

英文题名：Determination of Three Restricted Flavor Additives in Cigarettes by Solid-phase Extraction with Gas Chromatography-Tandem Mass Spectrometry

作者：郑阳[1,2];许秀丽[1];纪顺利[2];袁飞[1];黄志强[3];杨丙成[1];张峰[2]

机构：[1]华东理工大学药学院,上海200237;[2]中国检验检疫科学研究院烟草安全与控烟技术中心/食品安全研究所,北京100176;[3]湖南检验检疫科学技术研究院,湖南长沙410004

年份：2016

卷号：35

期号：8

起止页码：987

中文期刊名：分析测试学报

外文期刊名：Journal of Instrumental Analysis

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：质检公益性行业科研专项(201410088;201310134);中国检验检疫科学研究院基本科研业务费项目(2016JK009;2015JK008);国家质检总局科研计划项目(2014IK084);国家重大仪器设备开发专项(2012YQ14000806)

语种：中文

中文关键词：固相萃取;气相色谱-串联质谱;禁用香料;卷烟

外文关键词：solid phase extraction （SPE） ; gas chromatography - tandem mass spectrometry （ GC -MS/MS） ; restricted flavor additives; cigarettes

摘要：利用固相萃取结合气相色谱-串联质谱(SPE/GC-MS/MS)检测技术,建立了烟草制品中3种禁用香料(侧柏酮、樟脑及黄樟素)的高灵敏度分析方法。对前处理条件及质谱条件进行优化,在最佳实验条件下,3种香料在10.0~500.0μg/L质量浓度范围内的线性关系良好(r^2≥0.998 6),方法检出限(LOD,S/N=3)及定量下限(LOQ,S/N=10)分别为2.3~5.8μg/kg及7.7~19.3μg/kg。在LOQ,1.5LOQ及2LOQ加标水平下,3种禁用香料的平均回收率为74.9%~90.9%,相对标准偏差(RSD)均不大于2.6%。该方法准确可靠,灵敏度高,可满足国内对于这3种禁用香料的检测要求。
An analytical method for the simultaneous determination of three restricted flavor additives （3-thujanone, camphor and safrole） in tobacco products by solid-phase extraction with gas chroma- tography- tandem mass spectrometry （GC -MS/MS）was developed and evaluated. The extraction conditions and MS conditions were optimized. Under the optimal conditions, three flavor additives had good linearities in the range of 10. 0 -500.0 μg/L, with correlation coefficients （r2） not less than 0. 998 6. The limits of detection （LODs） and limits of quantitation （LOQs） for these additives were in the ranges of 2. 3 - 5.8 μg/kg and 7.7 - 19.3 μg/kg, respectively. The average recoveries of three analysts were in the range of 74.9% - 90. 9% at three spiked levels of LOQ, 1.5 LOQ and 2 LOQ, with relative standard deviations（RSDs） not more than 2.6%. The method is accurate, re- liable and sensitive, and could satisfy the requirements for detection of three restricted flavor additives in domestic.