文献类型：期刊文献

英文题名：Material-Mediated Immunotherapy to Regulate Bone Aging and Promote Bone Repair

作者：Xue, Pengfei[1,2];Wang, Jiayi[1,2];Fu, Yu[3];He, Hongyan[1,2,4];Gan, Qi[1,2,4];Liu, Changsheng[1,2,4,5]

机构：[1]East China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[3]Tongji Univ, Sch Aerosp Engn & Appl Mech, Zhangwu Rd 100, Shanghai 200092, Peoples R China;[4]East China Univ Sci & Technol, Engn Res Ctr Biomed Mat, Minist Educ, Shanghai 200237, Peoples R China;[5]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Shanghai 200237, Peoples R China

年份：2025

卷号：21

期号：11

外文期刊名：SMALL

收录：;EI(收录号：20250817921929);WOS:【SCI-EXPANDED(收录号:WOS:001426957800001)】；

基金：This work was supported by National Key Research and Development Program of China (No. 2022YFB3804300) and the National Natural Science Foundation of China (No. 32071337). This study was also supported by "the Fundamental Research Funds for the Central Universities."

语种：英文

外文关键词：biomaterials; bone aging; bone defects; immunotherapy

摘要：As the global population ages, an increasing number of elderly people are experiencing weakened bone regenerative capabilities, resulting in slower bone repair processes and associated risks of various complications. This review outlines the research progress on biomaterials that promote bone repair through immunotherapy. This review examines how manufacturing technologies such as 3D printing, electrospinning, and microfluidic technology contribute to enhancing the therapeutic effects of these biomaterials. Following this, it provides detailed introductions to various anti-osteoporosis drug delivery systems, such as injectable hydrogels, nanoparticles, and engineered exosomes, as well as bone tissue engineering materials and coatings used in immunomodulation. Moreover, it critically analyzes the current limitations of biomaterial-mediated bone immunotherapy and explores future research directions for material-mediated bone immunotherapy. This review aims to inspire new approaches and broaden perspectives in addressing the challenges of bone repair and aging by exploring innovative biomaterial-mediated immunotherapy strategies.