文献类型：期刊文献

英文题名：ε-Poly-L-Lysine Derived Fluorescent Carbon Dots for Infected Wound Healing Through Electrostatic Membrane Disruption and ROS Scavenging

作者：Yang, Biao[1];Teng, Runxin[1];Xu, Jiaxi[1];Liu, Shangpeng[1];Zhang, Zhuo[1];Hu, Wei[1];Sun, Min[2];Qin, Jinlong[3];Yang, Lin[4];Fan, Zhen[1]

机构：[1]Tongji Univ Mat Sci & Engn, Dept Polymer Mat, Shanghai, Peoples R China;[2]East China Univ Sci & Technol, Sch Mat Sci & Engn, Shanghai, Peoples R China;[3]Tongji Univ, Shanghai Peoples Hosp 4, Dept Gynaecol & Obstet, Shanghai, Peoples R China;[4]China Commun Construct Co, Wuhan Harbour Engn Design & Res Inst Co Ltd, Wuhan, Hubei, Peoples R China

年份：2026

卷号：43

期号：8

外文期刊名：PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION

收录：;EI(收录号：20263221258735);Scopus(收录号：2-s2.0-105046590905);WOS:【SCI-EXPANDED(收录号:WOS:001839137800001)】；

基金：This research was supported by the National Natural Science Foundation of China (22475154, 52573139), the International Scientific Collaboration Fund of the Science and Technology Commission of Shanghai Municipality (23520710900), and the Fundamental Research Funds for the Central Universities.

语种：英文

外文关键词：antibacterial; antioxidant; carbon dots; diabetes; wound healing

摘要：Diabetic wound, one of the most common diabetes complications, faces significant challenges with substantial medical and financial burdens. Clinically, conventional monotherapies struggle to disrupt the vicious cycle caused by persistent bacterial infections and a highly oxidative microenvironment. In this study, we developed poly-L-lysine and chitosan oligosaccharide lactate-based antibacterial and antioxidative carbon dots (epsilon-PLLCD) via a relatively low-temperature incomplete carbonization strategy, which preserves the structural integrity and intrinsic functional groups of the polymer precursors. Consequently, epsilon-PLLCD exhibits broad-spectrum bactericidal activity via electrostatic membrane disruption while concurrently acting as a potent ROS scavenger to neutralize the hyper-oxidative wound microenvironment. In vitro assays confirmed antibacterial and antioxidative capabilities of epsilon-PLLCD. Meanwhile, S. aureus-infected diabetic mouse model was applied, showing that epsilon-PLLCD significantly accelerated wound closure with nearly 100% healing on day 9. In addition, downregulation of IL-6 was also observed after mice were treated with epsilon-PLLCD, indicating effective antioxidative effects. Overall, this polypeptide-based carbon dot could provide a strategy for the clinical management of chronic diabetic wounds.