文献类型：期刊文献

英文题名：Facile fabrication of antioxidative and antibacterial hydrogel films to accelerate infected diabetic wound healing

作者：Zhang, Haodong[1];Liang, Qian[2];Ji, Yanxiu[2];Chen, Qi[1,2];Jiang, Weinan[3];Zhang, Donghui[1];Wu, Yueming[1,2];Yu, Liangmin[5,6];Chen, Wei[7,8,9,10];Liu, Runhui[1,2,3,4]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Met, Frontiers Sci Ctr Materiobiol & Dynam Chem,Key Lab, Engn Res Ctr Biomed Mat Minist Educ,Sch Mat Sci &, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Suzhou Inst Biomed Engn & Technol, Suzhou 215163, Peoples R China;[4]Fudan Univ, State Key Lab Mol Engn Polymers, Shanghai 200438, Peoples R China;[5]Ocean Univ China, Key Lab Marine Chem Theory & Technol, Minist Educ, Qingdao 266100, Peoples R China;[6]Ocean Univ China, Qingdao Collaborat Innovat Ctr Marine Sci & Techn, Qingdao 266100, Peoples R China;[7]Hebei Med Univ Third Hosp, Dept Orthoped Surg, Shijiazhuang, Hebei, Peoples R China;[8]Minist Educ, Engn Res Ctr Orthoped Minimally Invas Intelligent, Shijiazhuang, Hebei, Peoples R China;[9]NHC Key Lab Intelligent Orthoped Equipment, Shijiazhuang, Hebei, Peoples R China;[10]Key Lab Biomech Hebei Prov, Shijiazhuang, Hebei, Peoples R China

年份：2025

卷号：53

起止页码：386

外文期刊名：BIOACTIVE MATERIALS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:001554272800001)】；

基金：This research was supported by National Key R&D Program of China (2024YFC2418700) , the National Natural Science Foundation of China (No. T2325010) , Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism (Shanghai Municipal Education Commission) , the Fundamental Research Funds for the Central Universities (Nos. JKVD1241029 and JKD01241701) . We thank Research Center of Analysis and Test of East China University of Science and Technology for the help on the characterization. We also thank the staff members of the Integrated Laser Microscopy System at the National Facility for Protein Science in Shanghai (NFPS) , Zhangjiang Laboratory, China for providing technical support and assistance in data collection and analysis.

语种：英文

外文关键词：Antioxidative; Antibacterial; Hydrogel films; Infected diabetic wound healing; Wound dressing

摘要：Diabetic wounds are accompanied with hemorrhage, excessive reactive oxygen species accumulation, microbial infection, and poor exudate management. Current dressings are insufficient to modulate the complex pathophysiological microenvironment of infected diabetic wounds. Here, we develop a facile-fabricated hydrogel film with potent antibacterial and antioxidative properties to significantly accelerate infected diabetic wounds healing. The hydrogel film demonstrates potent antibacterial efficacy against methicillin-resistant Staphylococcus aureus and Escherichia coli, efficient scavenging of the extra- and intracellular reactive oxygen species, and enhanced fibroblast migration. In the methicillin-resistant Staphylococcus aureus infected diabetic wounds model, the hydrogel film treatment leads to reduced methicillin-resistant Staphylococcus aureus load, eliminated exudate accumulation, and significantly accelerated wound healing. In addition, the hydrogel film achieves rapid hemostasis by effective wound adhesion and fluid absorption. Collectively, this study provides a promising therapeutic option to promote infected diabetic wounds healing and management.