文献类型：会议论文

英文题名：Nucleation kinetics of lovastatin in different solvents from metastable zone widths

作者：Zhang, Xiangyang[1,2];Yang, Zhiqing[3];Chai, Jian[3];Xu, Jinyi[3];Zhang, Liang[3];Qian, Gang[1];Zhou, Xinggui[1]

机构：[1]E China Univ Sci & Technol, State Key Lab Chem Engn, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Prod Engn, Shanghai 200237, Peoples R China;[3]Hisun Co Ltd, Taizhou, Peoples R China

会议论文集：19th International Symposium on Industrial Crystallization

会议日期：SEP 16-19, 2014

会议地点：Toulouse, FRANCE

语种：英文

外文关键词：Metastable zone width; Lovastatin; Nucleation kinetics; Solvents

摘要：Cooling crystallization of lovastatin in methanol, ethanol and acetone was carried out and the metastable zone widths in those solutions were determined experimentally by the poMhermal method using a Turbidity Monitoring Technique. Two theoretical approaches, the self-consistent approach and classical 3D nucleation theory approach, were then employed to estimate the nucleation kinetics from the measured metastable zone width. The results suggested that nucleation in ethanol and acetone is instantaneous and follows polynuclear (RN) mechanism, while in methanol the nucleation is progressive with a high nucleation order. Because of the high solubility of lovastatin in these solvents, strong solute-solvent interactions exist, which make the activation energy for crystal formation different from that for self-diffusion. (C) 2015 Elsevier Ltd. All rights reserved.