文献类型：期刊文献

英文题名：Highly Enantioselective Michael Addition of 3-Aryloxindoles to Phenyl Vinyl Sulfone Catalyzed by Cinchona Alkaloid-Derived Bifunctional Amine-Thiourea Catalysts Bearing Sulfonamide as Multiple Hydrogen-Bonding Donors

作者：Zhao, Mei-Xin[1,2];Tang, Wen-Hao[1,2];Chen, Ming-Xiao[1,2];Wei, Deng-Ke[1,2];Dai, Tong-Lei[1,2];Shi, Min[1,2,3]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Adv Mat Lab, Shanghai 200237, Peoples R China;[2]Inst Fine Chem, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, State Key Lab Organometall Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

年份：2011

卷号：2011

期号：30

起止页码：6078

外文期刊名：EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000296318100015)，CCR-EXPANDED(收录号:WOS:000296318100015)】；

基金：We are grateful for financial support from the National Natural Science Foundation of China (NSFC) (grant numbers 20772030 and 21072056), the Fundamental Research Funds for the Central Universities, the Scientific Research Foundation for Returned Overseas Chinese Scholars, and the Ministry for State Education

语种：英文

外文关键词：Organocatalysis; Synthetic methods; Michael addition; Enantioselectivity; Heterocycles

摘要：A highly enantioselective Michael addition of 3-aryloxindole to phenyl vinyl sulfone catalyzed by a quinine-derived bifunctional amine-thiourea-bearing sulfonamide as multiple hydrogen-bonding donor catalyst has been investigated. The corresponding adducts, which contain a chiral quaternary carbon center at the 3-position of the oxindole, were obtained in moderate-to-good yields (52-86%) with high-to-excellent enantioselectivities (83-98% ee).