文献类型：期刊文献

中文题名：莫达非尼的合成

英文题名：Synthesis of Modafinil

作者：窦清玉[1];伍新燕[1];吴范宏[1]

机构：[1]华东理工大学化学与制药学院,上海200237

年份：2002

卷号：33

期号：3

起止页码：110

中文期刊名：中国医药工业杂志

外文期刊名：Chinese Journal of Pharmaceuticals

收录：CSTPCD;;北大核心:【北大核心2000】；CSCD:【CSCD2011_2012】；

语种：中文

中文关键词：莫达非尼;合成;合成路线

外文关键词：modafinil; central stimulant; synthesis

摘要：Modafinil, a new central stimulant, was synthesized from diphenylmethanol and 2-mercaptoacetic acid by a four-step reaction: condensation, chlorination, amination and then oxidation, in an overall yield of 58%.
Modafinil, a new central stimulant, was synthesized from diphenylmethanol and 2-mercaptoacetic acid by a four-step reaction: condensation, chlorination, amination and then oxidation, in an overall yield of 58%.