文献类型：期刊文献

中文题名：左氧氟沙星分子印迹膜固相萃取选择性分离氧氟沙星

英文题名：Levofloxacin-Imprinted Membranes for Selective Separation of Ofloxacin under Solid Phase Extraction Conditions

作者：邴乃慈[1];许振良[1];王学军[1];杨座国[1]

机构：[1]华东理工大学化学工程研究所,上海200237

年份：2007

卷号：33

期号：2

起止页码：163

中文期刊名：华东理工大学学报（自然科学版）

外文期刊名：Journal of East China University of Science and Technology

收录：CSTPCD;;EI(收录号：20072210628418);Scopus;北大核心:【北大核心2004】；CSCD:【CSCD2011_2012】；

基金：国家重点基础研究发展计划(973计划)资助项目(2003CB615705)

语种：中文

中文关键词：分子印迹膜;固相萃取;手性药物;左氧氟沙星

外文关键词：molecularly imprinted membrane; solid phase extraction; chiral drug; levofloxacin

摘要：以聚偏氟乙烯中空纤维超滤膜为支撑膜,左氧氟沙星(LVFX)为模板分子,采用热聚合方法制备了分子印迹聚合物膜,并应用于固相萃取选择性分离氧氟沙星外消旋体(OFLX)。通过紫外光谱法研究了模板分子与功能单体之间的相互作用,得到了单体α-甲基丙烯酸和模板分子LVFX缔合的化学计量数2和结合常数K=3.83×105L2/mol2;用扫描电镜表征膜的表面形貌;固相萃取实验结果表明:分子印迹聚合物膜中存在着空间结构和大小均与模板分子LVFX互补的孔穴组成的通道,该通道可选择性地透过底物分子,得到的LVFX和OFLX的最大分配系数KL和KO分别为2.7和2。该方法为分子印迹膜萃取技术用于手性药物拆分提供了理论和实验方法。
Using polyvinylidene foluoride hollow fiber uhrafihration membrane as the supported membranes and the levofloxacin as the template, the molecularly imprinted membranes were prepared by thermal copolymerization. The interaction between the template and functional monomer is proved, and the binding constant is 3.83 ×10^5 L^2/mol^2 and chemical combination ratio is 2. The surface features of membranes were analyzed by scan electron micrographs. The solid phase extraction experiments show there are paths in the molecularly imprinted membranes which formed by the cavities with size and structure accommodated to levofloxacin and showed a better selectivity for it. Distributed coefficient K of the membranes to LVFX and OFLX could reach 2. 7 and 2. This work increases the application of imprinted membrane extraction in chiral drug separation.