文献类型：期刊文献

中文题名：官能团化聚己内酯的制备及其生物应用

英文题名：Synthesis of Functionalized Poly(ε-caprolactone)s and their Biological Applications

作者：张俊[1];肖艳[1,2];徐衡[3];严金良[1];郎美东[1,2]

机构：[1]华东理工大学材料科学与工程学院,上海200237;[2]上海生物制造产业协同创新中心,上海200237;[3]石油化工新材料协同创新中心,安庆246011

年份：2016

期号：5

起止页码：13

中文期刊名：高分子通报

外文期刊名：Polymer Bulletin

收录：CSTPCD;;北大核心:【北大核心2014】；CSCD:【CSCD2015_2016】；

基金：国家自然科学基金(21274039);高等学校博士学科点专项科研基金(20130074110007)

语种：中文

中文关键词：聚己内酯;官能团化;药物缓释;组织工程

外文关键词：PCL; Functional; Drug delivery; Tissue engineering

摘要：聚己内酯(PCL)是一种疏水的、半结晶的、可降解的脂肪族聚合物,其具有良好的生物相容性、药物透过性和机械性能,在药物缓释和组织工程领域得到了广泛的关注。由于其结晶性强,亲水性差,生物降解速度慢,限制了其在生物医用领域更广泛的应用。聚己内酯的官能团化可实现对聚酯材料亲疏水性、降解速率等物化性质的调节,同时,活性官能团的引入便于对PCL的进一步化学修饰,有利于拓宽聚己内酯类材料的生物医用领域。本文详细介绍在聚己内酯骨架引入侧基官能团的化学方法,并简要阐述了官能团化聚己内酯在生物医用材料领域的应用。
Polycaprolactone（PCL） is a hydrophobie, semi-crystalline and biodegradable aliphatic polymer. A good biocompatibility and mechanical properties of PCL has stimulated extensive attention in the drug delivery and tissue engineering. However, the major drawback of the PCL is highly crystalline, low hydrophilic and slow biodegradation which limited its widely application in the biomedical field. The introduction of functional groups into commonly used PCL make it possible to further chemical modification as well as tune its physicochemical properties such as hydrophilicity and degradation rate, which makes PCL more suitable for biomedical applications. This review will focus on the prepared method of PCL with pendent functional groups, and briefly discussed its application in the biomedical areas.