文献类型：期刊文献

英文题名：Small-molecule fluorescence-based probes for interrogating major organ diseases

作者：Han, Hai-Hao[1,2];Tian, He, Jr.[1,2];Zang, Yi[3];Sedgwick, Adam C.[4];Li, Jia[3];Sessler, Jonathan L.[4];He, Xiao-Peng[1,2];James, Tony D.[5,6]

机构：[1]East China Univ Sci & Technol, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Sci Joint Res Ctr, Sch Chem & Mol Engn,Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Ctr Mat & Dynam Chem, Feringa Nobel Prize Sci Joint Res Ctr, Sch Chem & Mol Engn,Joint Int Res Lab Precis Chem, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]Chinese Acad Sci, Shanghai Inst Mat Med, Natl Ctr Drug Screening, State Key Lab Drug Res, 189 Guo Shoujing Rd, Shanghai 201203, Peoples R China;[4]Univ Texas Austin, Dept Chem, 105 E 24th St,A5300, Austin, TX 78712 USA;[5]Univ Bath, Dept Chem, Bath BA2 7AY, Avon, England;[6]Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China

年份：2021

卷号：50

期号：17

起止页码：9391

外文期刊名：CHEMICAL SOCIETY REVIEWS

收录：;EI(收录号：20213610873098);WOS:【SCI-EXPANDED(收录号:WOS:000670372900001)】；

基金：X.-P. H. thanks the National Natural Science Foundation of China (No. 21788102, 91853201), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017) for financial support. H.-H. H. would like to thank the Project funded by China Postdoctoral Science Foundation (No. 2020M681196). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). Support from the Robert A. Welch Foundation (F-0018 to J. L. S.) is also gratefully acknowledged.

语种：英文

外文关键词：Fluorescence - Fluorescence spectroscopy - Biocompatibility - Molecules - Probes

摘要：Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate in vitro and in vivo biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes in vitro and in vivo. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases.