文献类型：期刊文献

英文题名：Site-selective deuteration at the α-position of enals by an amine and bis(phenylsulfonyl)methane co-catalyzed H/D exchange reaction

作者：Qian, Pengfei[1,2,3,4];Zhang, Shilei[3,4];Luo, Fan[1,2];Wang, Jiarui[1,2];Zhang, Xinyu[1,2];Liu, Xuejun[5];Chen, Xiaodong[5];Wang, Wei[1,2,6,7];Chen, Xiaobei[1,2]

机构：[1]East China Univ Sci & Technol, Shanghai Frontiers Sci Ctr Optogenet Tech Cell Me, Sch Pharm, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Sch Pharm, State Key Lab Bioengn Reactor, Shanghai 200237, Peoples R China;[3]Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;[4]Soochow Univ, Coll Pharmaceut Sci, 199 Renai Rd, Suzhou 215123, Jiangsu, Peoples R China;[5]Shanghai Neutan Pharmaceut Co Ltd, Bldg 26,555 Huanqiao Rd, Shanghai, Peoples R China;[6]Univ Arizona, Dept Pharmacol & Toxicol, 1703 E Mabel St,POB 210207, Tucson, AZ 85721 USA;[7]Univ Arizona, BIO5 Inst, 1703 E Mabel St,POB 210207, Tucson, AZ 85721 USA

年份：2022

卷号：58

期号：81

起止页码：11458

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;EI(收录号：20224212975898);WOS:【SCI-EXPANDED(收录号:WOS:000859800600001)，CCR-EXPANDED(收录号:WOS:000859800600001)】；

基金：We acknowledge financial support from the National Natural Science Foundation of China (22071053 and 22271206), Shanghai Frontiers Science Center of Optogenetic Techniques for CellMetabolism (Shanghai Municipal Education Commission, grant 2021 Sci & Tech 03-28), and PAPD (A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions).

语种：英文

外文关键词：Catalysis - Methane

摘要：An amine and bis(phenylsulfonyl)methane co-catalyzed hydrogen-deuterium exchange (HDE) method via a Michael-retro-Michael pathway for site-selective introduction of deuterium at the ccposition of enals using D2O as a deuterium source has been achieved. The mild, operationally simple protocol allows for high yielding and high level deuterium incorporation (up to 99%) for structurally diverse aromatic-derived enals and dienals.