文献类型：期刊文献

英文题名：Sustained release of VH and rhBMP-2 from nanoporous magnesium-zinc-silicon xerogels for osteomyelitis treatment and bone repair

作者：Li, Fengqian[1];Wu, Wen[2];Xiang, Li[1];Weng, Gan[1];Hong, Hua[3];Jiang, Hong[4];Qian, Jun[3]

机构：[1]Shanghai Jiao Tong Univ, Shanghai Xuhui Dahua Hosp, Dept Pharm, Shanghai 200030, Peoples R China;[2]E China Univ Sci & Technol, Peoples Hosp 9, Sch Med, Dept Orthopaed, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Key Lab Ultrafine Mat, Minist Educ, Shanghai 200237, Peoples R China;[4]Univ Shanghai Sci & Technol, Sch Mat Sci & Engn, Shanghai, Peoples R China

年份：2015

卷号：10

起止页码：4071

外文期刊名：INTERNATIONAL JOURNAL OF NANOMEDICINE

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000356593800001)】；

基金：This study was supported by grants from the National Natural Science Foundation of China (numbers 81172989 and 81301546), the Major Program of Natural Science Foundation of Shanghai, China (13NM1400702), the National Science Fund of Shanghai (number 13ZR1427900), and the Shanghai Education Development Foundation (number Slgl4050).

语种：英文

外文关键词：nanoporous xerogels; sustained release; drugs; osteomyelitis; bone regeneration; bactericidal activity; cytocompatibility

摘要：Nanoporous magnesium-zinc-silicon (n-MZS) xerogels with a pore size of similar to 4 nm, a surface area of 718 cm(2)/g, and a pore volume of 1.24 cm(3)/g were synthesized by a sol-gel method. The n-MZS xerogels had high capacity to load vancomycin hydrochloride (VH) and human bone morphogenetic protein-2 (rhBMP-2), after soaking in phosphate buffered saline (PBS) for 24 hours (1.5 and 0.8 mg/g, respectively). Moreover, the n-MZS xerogels exhibited the sustained release of VH and rhBMP-2 as compared with magnesium-zinc-silicon (MZS) xerogels without nanopores (showing a burst release). The VH/rhBMP-2/n-MZS system not only exhibited a good antibacterial property but also promoted the MG63 cell proliferation and differentiation demonstrating good bactericidal activity and cytocompatibility. The results suggested that n-MZS with larger surface area and high pore volume might be a promising carrier for loading and sustained release of VH and rhBMP-2. Hence, the VH/rhBMP-2/n-MZS system might be one of the promising biomaterials for osteomyelitis treatment and bone repair.