文献类型：期刊文献

英文题名：Self-assembled monolayers for bio-analytical SERS applications: from single to mixed component SAMs

作者：Cheng, Tao[1,2];Li, Chunchun[3,4];Ye, Ziwei[1,2];Ye, Jian[5,6];Bell, Steven E. J.[4];Xu, Yikai[1,2]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Frontiers Sci Ctr Materiobiol & Dynam Chem, Key Lab Adv Mat, 130 Meilong Rd, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Feringa Nobel Prize Scientist Joint Res Ctr, Frontiers Sci Ctr Materiobiol & Dynam Chem, Sch Chem & Mol Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[3]East China Univ Sci & Technol, Sch Mat Sci & Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China;[4]Queens Univ Belfast, Sch Chem & Chem Engn, Univ Rd, Belfast BT7 1NN, North Ireland;[5]Shanghai Jiao Tong Univ, Peoples Hosp 6, Sch Med, Shanghai 200030, Peoples R China;[6]Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China

年份：2026

外文期刊名：MATERIALS HORIZONS

收录：;EI(收录号：20260820093820);WOS:【SCI-EXPANDED(收录号:WOS:001692165700001)】；

基金：The authors would like to thank Prof He Tian, Prof Xiang Ma and Prof Xin Xu for support. The authors would like to acknowledge the following funding. Natural Science Foundation of China 22503032, 22573031, 22503031. Natural Science Foundation of Shanghai 24ZR1416700. Shanghai Pujiang Program 23PJ1409000.

语种：英文

外文关键词：Plasmonics - Substrates - Surface chemistry

摘要：Self-assembled monolayers (SAMs) represent an elegant and powerful strategy for achieving precise control over the surface chemistry of plasmonic nanomaterials. This capability has significantly advanced both fundamental and applied research in surface-enhanced Raman spectroscopy (SERS), a technique whose performance is critically dependent on the chemical nature of the enhancing substrate. While single-component SAMs have served as a cornerstone in foundational SERS studies, their functionality is inherently limited, rendering them inadequate for complex real-world applications. Mixed-component SAMs offer a compelling solution by enabling the integration of multiple functional ligands on a single plasmonic interface, thereby overcoming these limitations. Nevertheless, the routine and reliable deployment of mixed component SAMs in SERS faces fundamental challenges, particularly in their controlled synthesis and precise characterization. As a result, despite their widespread empirical use, the field of mixed-component SAMs remains underdeveloped and insufficiently reviewed. This article aims to address this gap by first outlining the fundamentals of single-component SAMs, then delving into the synthesis strategies and characterization techniques specific to mixed component SAMs. We emphasize the unique role of SERS as a powerful in situ tool for probing key parameters of mixed monolayers. Using biological applications as a primary example, we illustrate how the multifunctionality afforded by mixed component SAMs leads to enhanced sensitivity, selectivity, stability, and accuracy in quantitative SERS analysis. Finally, we discuss the persisting challenges in the rational design of mixed component SAMs, highlighting the need for further mechanistic research and the integration of artificial intelligence.