文献类型：期刊文献

英文题名：Biodegradable peptide polymers as alternatives to antibiotics used in aquaculture

作者：Ma, Pengcheng[1];Wu, Yueming[2];Jiang, Weinan[2];Shao, Ning[2];Zhou, Min[1];Chen, Yuan[2];Xie, Jiayang[2];Qiao, Zhongqian[2];Liu, Runhui[1,2]

机构：[1]East China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[2]East China Univ Sci & Technol, Frontiers Sci Ctr Materiobiol & Dynam Chem, Res Ctr Biomed Mat, Sch Mat Sci & Engn,Minist Educ,Key Lab Ultrafine, Shanghai 200237, Peoples R China

年份：2022

卷号：10

期号：15

起止页码：4193

外文期刊名：BIOMATERIALS SCIENCE

收录：;EI(收录号：20222612297102);WOS:【SCI-EXPANDED(收录号:WOS:000814220800001)】；

基金：This research was supported by the National Natural Science Foundation of China (No. 22075078 and 21861162010), the National Key Research and Development Program of China (2016YFC1100401), the Program of Shanghai Academic/Technology Research Leader (20XD1421400), the Natural Science Foundation of Shanghai (18ZR1410300), the Research Program of State Key Laboratory of Bioreactor Engineering, and the Fundamental Research Funds for the Central Universities. The authors thank Wenwen Wang and Professor Qin Liu at the East China University of Science and Technology for their help with zebrafish breeding, the Research Center of Analysis and Test of East China University of Science and Technology for help with the characterization, and ZEISS Microscopy Shanghai Customer Center for help with confocal microscopy.

语种：英文

外文关键词：Antibiotics - Aquaculture - Bacteria - Biodegradable polymers - Disease control

摘要：The pressure of antimicrobial resistance has forced many countries to reduce or even prohibit the use of antibiotics in feed. Therefore, it is an urgent need to develop alternatives to antibiotics to control infectious diseases in feed and aquaculture. To address this long-lasting challenge, we prepared peptide polymers that display potent and broad-spectrum activity against common pathogenic bacteria in aquaculture, low hemolysis and low cytotoxicity, and do not induce bacteria to develop resistance or cross-resistance to antibiotics. The optimal peptide polymer demonstrates strong in vivo therapeutic potential in an adult zebrafish infection model. Moreover, the optimal peptide polymer is biodegradable by enzymes into single amino acids and dipeptides to totally lose its antibacterial activity and, therefore, will not cause antimicrobial selective pressure. Our study suggests that peptide polymers are promising alternatives to antibiotics in aquaculture and open new avenues to address the global challenge of antimicrobial resistance.