文献类型：期刊文献

英文题名：The Mechanism of Acrylamide-Induced Neurotoxicity: Current Status and Future Perspectives

作者：Zhao, Mengyao[1,2];Zhang, Boya[1];Deng, Linlin[1]

机构：[1]East China Univ Sci & Technol, Sch Biotechnol, State Key Lab Bioreactor Engn, Shanghai, Peoples R China;[2]Shanghai Collaborat Innovat Ctr Biomfg Technol SCI, Shanghai, Peoples R China

年份：2022

卷号：9

外文期刊名：FRONTIERS IN NUTRITION

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000791395400001)】；

基金：Funding The National Natural Science Foundation for Young Scientists of China (No. 31801668), The Fundamental Research Funds for the Central Universities (No. 222201814036), The Shanghai PuJiang Program (No. 18J1401900), and The National Key R&D Program of China (No. 2019YFD090180302).

语种：英文

外文关键词：acrylamide; neurotoxicity; oxidative stress; apoptosis and autophagy; inflammation; gut-brain axis

摘要：Acrylamide (ACR), a potential neurotoxin, is produced by the Maillard reaction between reducing sugars and free amino acids during food processing. Over the past decade, the neurotoxicity of ACR has caused increasing concern, prompting many related studies. This review summarized the relevant literature published in recent years and discussed the exposure to occupational, environmental, and daily ACR contamination in food. Moreover, ACR metabolism and the potential mechanism of ACR-induced neurotoxicity were discussed, with particular focus on the axonal degeneration of the nervous system, nerve cell apoptosis, oxidative stress, inflammatory response, and gut-brain axis homeostasis. Additionally, the limitations of existing knowledge, as well as new perspectives, were examined, specifically regarding the connection between the neurotoxicity caused by ACR and neurodegenerative diseases, NOD-like receptor protein 3 (NLRP3) inflammasome-related neuroinflammation, and microbiota-gut-brain axis signaling. This review might provide systematic information for developing an alternative pathway approach to assess ACR risk.