文献类型：期刊文献

英文题名：Mesoporous manganese silicate coated silica nanoparticles as multi-stimuli-responsive T1-MRI contrast agents and drug delivery carriers

作者：Li, Xiaowei[1];Zhao, Wenru[1];Liu, Xiaohang[2];Chen, Kaiqiang[1];Zhu, Shaojia[3];Shi, Ping[3];Chen, Yu[4];Shi, Jianlin[1,4]

机构：[1]E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China;[2]Fudan Univ, Shanghai Canc Ctr, Dept Radiol, Shanghai 200032, Peoples R China;[3]E China Univ Sci & Technol, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China;[4]Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China

年份：2016

卷号：30

起止页码：378

外文期刊名：ACTA BIOMATERIALIA

收录：;EI(收录号：20215111342812);WOS:【SCI-EXPANDED(收录号:WOS:000368563600034)】；

基金：This study was financially supported by 973 Program (Grant No. 2012CB933602), the National Natural Science Foundation of China (Grant Nos. 5141101086, 51172070, 51572084), the Natural Science Foundation of Shanghai (Grant No. 14ZR1410100), the Fundamental Research Funds for the Central Universities (222201313010), and the Nano-Special Foundation for Shanghai Committee of Science and Technology (12nm0502600).

语种：英文

外文关键词：Manganese silicate; Stimuli-responsive; T-1-weighted MRI; Contrast agents; Drug delivery

摘要：A novel kind of monodisperse mesoporous manganese silicate coated silica nanoparticle (MMSSN) as a highly efficient T-1-weighted MRI contrast agent (CA) and drug carrier for cancer diagnosis and chemotherapy has been constructed by a modified "SiO2 sacrifice and in situ silicate growth" approach under a relatively low hydrothermal temperature and alkali-free condition. The mesoporous manganese silicate shell provides a large specific surface area and abundant exposed Mn paramagnetic centers to water molecules, which endows the MMSSN5 with extraordinarily high longitudinal relaxivity. Meanwhile, the MMSSNs presented an efficient pH/redox-responsive T-1-MRI feature based on the significant enhancement of relaxation rate (r(1)) stimulated by mild acidic environment or reducing agent (GSH) both in vitro and in vivo. Furthermore, the mesoporous structure and negatively charged pore surface of the manganese silicate shell enable the MMSSN5 to attain anti-cancer drug (DOX) storage and a pH-responsive release, which is suitable for on-demand drug release for the chemotherapy of tumors. Therefore, the mesoporous manganese silicate-based nanomaterial is a promising candidate as T-1-MRI CAs and anticancer-drug delivery carriers for the theranostics of tumor in an intelligent and on-demand manner. Statement of significance MRI is one of the most frequently used imaging techniques in daily clinics for cancer diagnosis. Using contrast agents (CAs) in MRI can afford much clearer and enlarged images of detectable organs. Gadolinium (Gd3+)-based T-1-positive CAs are widely used but associated with the risk of nephrogenic systemic fibrosis. To achieve much safer CAs, various Mn2+-based T-1-positive CAs have been reported, such as MnO or core-shell MnOx-based nanoparticles. However, the efficiency of these CAs is still lower. Herein, we report a novel kind of mesoporous manganese silicate coated silica nanoparticle as CA and anti-cancer drug carrier. Results obtained from this study, especially the pH/redox-responsive T-1-MRI feature are helpful for us to further design efficient MnSiO3-based materials for clinical MRI applications. (C) 2015 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.