文献类型：期刊文献

英文题名：Alkyl detection facilitated by a DNA conjugate with an α-hemolysin nanopore

作者：Hu, Zheng-Li[1,2];Cao, Chan[1,2];Wang, Hui-Feng[3];Yan, Bing-Yong[4]

机构：[1]E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Dept Chem, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Shanghai 200237, Peoples R China;[4]E China Univ Sci & Technol, Sch Informat Sci & Engn, Shanghai 200237, Peoples R China

年份：2016

卷号：6

期号：1

起止页码：105

外文期刊名：RSC ADVANCES

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000367250900015)】；

基金：This work was supported by the National Natural Science Foundation of China (51407078). B.-Y. Yan is supported by the Fundamental Research Funds for the Central Universities (WH1514049).

语种：英文

摘要：Herein an alpha-hemolysin nanopore was utilized to detect a DNA conjugate, where a propyl linker was attached to the 20-mer oligo-nucleotides at each end of an individual strand. The studies showed the alkyl linker produced a clear current change when translocating through the protein pore, which could be used to sense and identify small organic molecule at the single-molecule level.