文献类型：期刊文献

中文题名：用于药物载体的多重响应型聚合物分子的设计与合成

英文题名：Design and Synthesis of Multi-Responsive Copolymers for Drug Carrier

作者：王义洲[1,2];刘晔宏[1,2];徐首红[1,2];刘洪来[1,2]

机构：[1]华东理工大学,结构可控先进功能材料及其制备教育部重点实验室,上海200237;[2]华东理工大学化学与分子工程学院,上海200237

年份：2019

卷号：35

期号：8

起止页码：876

中文期刊名：物理化学学报

外文期刊名：Acta Physico-Chimica Sinica

收录：CSTPCD;;Scopus;WOS:【SCI-EXPANDED(收录号:WOS:000472714900017)】；北大核心:【北大核心2017】；CSCD:【CSCD2019_2020】；PubMed;

基金：The project was supported by the National Natural Science Foundation of China (21776071, 51621002).

语种：中文

中文关键词：原子转移自由基聚合;低临界溶解温度;pH/温度双重响应;聚合物胶束;可控释药

外文关键词：ATRP;LCST;pH/temperature dual-responsive;Copolymer micelle;Controlled release

摘要：利用原子转移自由基聚合(ATRP)法和连续ATRP法合成了温度敏感型聚合物和pH/温度双重敏感型聚合物。用紫外光谱考察聚合物在水溶液中的温敏行为,发现聚合物的低临界溶解温度(LCST)可以通过单体的比例进行调控,而且聚合物的温度响应行为非常敏感且具有可逆性。pH/温度双重敏感型聚合物还具有非常灵敏的pH响应行为,且不受单体比例的影响。最后,对聚合物胶束的体外释药动力学进行了研究,结果表明聚合物胶束的环境敏感性决定了药物的释放行为。
A copolymer P(MEO2MAm-co-OEGMAn)-b-PDPAp(poly[di(ethylene glycol)methyl ether methacrylate-co-oligo(ethylene glycol)methacrylate]-b-poly[2-(diisopropylamino)ethyl methacrylate])had been designed to have good stimuli-response for developing temperature/pH dual-responsive drug delivery systems.In this study,the copolymer was synthesized in two steps:atom transfer radical polymerization(ATRP)method,followed by the continuous ATRP method for P(MEO2MAm-co-OEGMAn)and P(MEO2MAm-co-OEGMAn)-b-PDPAp,respectively.The data of proton nuclear magnetic resonance spectroscopy(1H NMR)and gel permeation chromatography(GPC)showed that the chemical compositions of the two copolymers could be precisely controlled.The aqueous solution properties of the copolymers were investigated using a UV-visible spectrophotometer.Results showed that the former random copolymers had reversible temperature response,while the end product exhibited temperature/pH dual-responsive behaviors.Their lower critical solution temperatures(LCSTs)were found to be dependent on the ratios of the monomers.Firstly,the relationship between the monomer ratio and the low critical solution temperature(LCST)of P(MEO2MAm-co-OEGMAn)was investigated.It was found that within the range of the experimental study(m+n=100,0