文献类型：期刊文献

英文题名：A 4-OTBS benzyl-based protective group for carboxylic acids

作者：Fang, Zhijun[1];Li, Yuyao[1];Xie, Hexin[1]

机构：[1]East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China

年份：2019

卷号：60

期号：25

起止页码：1658

外文期刊名：TETRAHEDRON LETTERS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000472813100009)】；

基金：This work was financially supported by "Thousand Plan" Youth Program, the Fundamental Research Funds for the Central Universities, and East China University of Science & Technology.

语种：英文

外文关键词：Protective group; Carboxylic acid; 4-OTBS benzyl; GGT probe

摘要：Reported herein is a novel 4-OTBS benzyl-based protective group for carboxylic acids. This protective group can be removed in the presence of TBAF or TFA with high efficiency, which makes it compatible with base-sensitive or acid-sensitive substrates. With this protective group, a near-infrared fluorogenic probe for the detection of gamma-glutamyltranspeptidase activities was readily prepared. (C) 2019 Elsevier Ltd. All rights reserved.