文献类型：期刊文献

英文题名：Rational design of biotinylated probes: fluorescent turn-on detection of (strept)avidin and bioimaging in cancer cells

作者：Sun, Qian[1];Qian, Junhong[1];Tian, Haiyu[1];Duan, Liping[2];Zhang, Weibing[1]

机构：[1]E China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai 200032, Peoples R China

年份：2014

卷号：50

期号：62

起止页码：8518

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000339228500016)】；

基金：This work was financially supported by National 973 Program (No. 2011CB910403), NSFC (No. 21235005), Shanghai Municipal Natural Science Foundation (12ZR1434900) and the Opening Project of Shanghai Key Laboratory of New Drug Design (Grant No. 11DZ2260600). We appreciate Prof. A. M. Brouwer (University of Amsterdam) for improving our paper.

语种：英文

摘要：Two fluorescent probes SPS1 and SPS2 were designed by connecting biotin to an environment-sensitive coumarin fluorophore. Streptavidin and avidin induced dramatical fluorescence changes in both probes. SPS2 has potential in fluorescent imaging of biotin receptor-enriched tumor cells.