文献类型：期刊文献

英文题名：A fluorescence turn-on probe for human (bovine) serum albumin based on the hydrolysis of a dioxaborine group promoted by proteins

作者：Sun, Qian[1];Wang, Weisi[2];Chen, Zhaoyang[1];Yao, Yuhua[1];Zhang, Weibing[1];Duan, Liping[2];Qian, Junhong[1]

机构：[1]East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[2]Chinese Ctr Dis Control & Prevent, Natl Inst Parasit Dis, Shanghai 200032, Peoples R China

年份：2017

卷号：53

期号：48

起止页码：6432

外文期刊名：CHEMICAL COMMUNICATIONS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000403211300011)】；

基金：This work was financially supported by the National Natural Science Foundation of China (NSFC No. 21576085, 21475044) and the Shanghai Municipal Natural Science Foundation (15ZR1409000).

语种：英文

摘要：A fluorescence "off-on'' probe CBF, constructed by incorporating a dioxaborine unit into a microenvironment-sensitive fluorophore, was developed for serum albumin (SA). Upon binding to SA, the dioxaborine group in CBF was hydrolyzed into beta-diketonate, which triggered dramatic fluorescence enhancement (over 1000-fold) along with a remarkable blue-shift (similar to 100 nm). The bioimaging results suggested that more SA were taken in by cancer cells.