文献类型：期刊文献

英文题名：Evaluation of Drug Release Profile from Patches Based on Styrene-Isoprene-Styrene Block Copolymer: The Effect of Block Structure and Plasticizer

作者：Wang, ChengXiao[1,2];Han, Wei[1];Tang, XiuZhen[2];Zhang, Hao[1,2]

机构：[1]E China Univ Sci & Technol, Dept Pharm, Shanghai 200237, Peoples R China;[2]Natl Engn Res Ctr Tradit Chinese Med, Shanghai 201203, Peoples R China

年份：2012

卷号：13

期号：2

起止页码：556

外文期刊名：AAPS PHARMSCITECH

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000304651900023)】；

基金：This research was supported by the National Science and Technology Key Program for the 11th five-year Plan of China (2008BAI53B075).

语种：英文

外文关键词：drug delivery; Peppas equation; rheology; thermoplastic elastomer

摘要：We prepared pressure-sensitive adhesive (PSA) patches based on styrene-isoprene-styrene (SIS) thermoplastic elastomer using hot-melt coating method. The liquid paraffine is added in the PSA matrices as a plasticizer to moderate the PSA properties. Three drugs, methyl salicylate, capsaicin, and diphenhydramine hydrochloride are selected as model drugs. The Fourier transform infrared spectroscopy, differential scanning calorimetry test, and wide-angle X-ray diffraction test indicate a good compatibility between drugs and matrices. Peppas equation is used to describe drug release profile. Different drug-matrix absorption, as indicative of drug-matrix interaction, accounts for the variation in release profiles of different drugs. Furthermore, atomic force microscopy and rheological studies of the PSA samples are performed to investigate the effect of SIS structure and plasticizer of PSA on drug release behaviors. For methyl salicylate and capsaicin, drug diffusion in the PSA matrices is the main factor controlled by the release kinetic constant k. The high [SI] diblock content and high plasticizer amount in matrix provide the PSA with a homogeneous and soften microstructure, resulting in a high diffusion rate. But for water-soluble drugs such as diphenhydramine hydrochloride, the release rate is governed by water penetration with the competition from diffusion mechanisms.