文献类型：期刊文献

英文题名：An Efficient and Convenient Protocol for Highly Regioselective Cleavage of Terminal Epoxides to β-Halohydrins

作者：Wang, Tao[1];Ji, Wen-Hao[1];Xu, Zhong-Yu[1];Zeng, Bu-Bing[1]

机构：[1]E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China

年份：2009

期号：9

起止页码：1511

外文期刊名：SYNLETT

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000267168600033)，CCR-EXPANDED(收录号:WOS:000267168600033)】；

基金：This work is financially supported by Shanghai Municipal Committee of Science and Technology (064319022), 111 project (1307023), the national '863' Project of China (2006AA609Z447 and 2007AA02Z301) and Shanghai Pujian Program (05PJ14035).

语种：英文

外文关键词：epoxide; beta-halohydrin; cleavage; regioselectivity; chemoselectivity

摘要：An efficient and facile strategy for the cleavage of terminal epoxides to beta-halohydrins using active magnesium halides is described. The conversion proceeds smoothly at room temperature with high regioselectivity and good yields even when sensitive functional groups are present.