文献类型：期刊文献

英文题名：Chitosan-graft-β-cyclodextrin nanoparticles as a carrier for controlled drug release

作者：Yuan, Zeting[2];Ye, Yajing[2];Gao, Feng[1,2,3];Yuan, Huihui[3];Lan, Minbo[3];Lou, Kaiyan[1];Wang, Wei[1,4]

机构：[1]E China Univ Sci & Technol, Shanghai Key Lab New Drug Design, Shanghai 200237, Peoples R China;[2]E China Univ Sci & Technol, Sch Pharm, Dept Pharmaceut, Shanghai 200237, Peoples R China;[3]E China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Shanghai 200237, Peoples R China;[4]Univ New Mexico, Dept Chem & Chem Biol, Albuquerque, NM 87131 USA

年份：2013

卷号：446

期号：1-2

起止页码：191

外文期刊名：INTERNATIONAL JOURNAL OF PHARMACEUTICS

收录：;WOS:【SCI-EXPANDED(收录号:WOS:000316736500024)】；

基金：The authors acknowledge the financial support from the Fundamental Research Funds for the Central Universities (WY1213013 ECUST), Shanghai Nanotechnology Leading Academic Discipline Foundation (No. 0852nm05900) and 111 Program of China (No. B07023). This work was also supported by Shanghai Committee of Science and Technology (Grant No. 10DZ2220500 and 11DZ2260600).

语种：英文

外文关键词：Chitosan; Cyclodextrin; Ionic gelation; Nano-drug delivery system

摘要：Chitosan (CS) grafted with beta-cyclodextrin (CD-g-CS) nanoparticles as a new carrier for poorly water-soluble drugs has been developed. The CD-g-CS polymer is readily synthesized from chitosan and mono-6-deoxy-6-(p-toluenesulfonyl)-beta-cyclodextrin. Three different degrees of substitution (DS) of beta-cyclodextrin (beta-CD) on CD-g-CS (9.6, 14.0 and 20.0%) are designed and evaluated by controlling the mole ratio of beta-CD to chitosan. Then CD-g-CS nanoparticles are prepared by an ionic gelation method, with the controlled size of 202.0-589.0 nm. Stable colloidal dispersion of the nanoparticles has been formed with the zeta potential of +23.0 to +43.0 mV. In vitro stability test indicates that CD-g-CS nanoparticles are more stable in phosphate-buffered saline compared with CS nanoparticles. Finally, the poorly water-soluble drug, ketoprofen (KTP), is used as a model drug to evaluate the efficiency of the new drug delivery carrier. It is found that the encapsulation efficiency of KTP in the nanoparticles with 20% DS of CD is as high as 1.36-fold than that of CS nanoparticles. Moreover, notably KTP is released from the nanoparticles in a controlled-release manner and is pH-responsive on DS of CD. In summary, these results suggest that the CD-g-CS nanoparticles, as a general promising drug delivery system, can be used as a potential biodegradable nano-drug delivery system for controlled release of poorly water-soluble drugs with pH-responsive capability. (C) 2013 Elsevier B. V. All rights reserved.