文献类型：期刊文献

英文题名：Serum metabolome biomarkers associate low-level environmental perfluorinated compound exposure with oxidative /nitrosative stress in humans

作者：Wang, Xiaofei[1,2];Liu, Liangpo[2];Zhang, Weibing[1];Zhang, Jie[2];Du, Xiaoyan[2];Huang, Qingyu[2];Tian, Meiping[2];Shen, Heqing[2]

机构：[1]East China Univ Sci & Technol, Shanghai Key Lab Funct Mat Chem, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China;[2]Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen, Peoples R China

年份：2017

卷号：229

起止页码：168

外文期刊名：ENVIRONMENTAL POLLUTION

收录：;EI(收录号：20172303749687);WOS:【SCI-EXPANDED(收录号:WOS:000410010200018)】；

基金：This work was financially supported by the State Key Program of National Natural Science of China (21235005), the National Natural Science Foundation of China (No. 21177123, 21311130119, 21475044, 21407143, 21677141), Youth Innovation Promotion Association CAS (2015246) and the Knowledge Innovation Program of the Chinese Academy of Sciences (IUEZD201401).

语种：英文

外文关键词：Perfluorinated compound; Serum; Metabolome; Oxidative stress; Nitrosative stress

摘要：Previous in vivo and in vitro studies have linked perfluorinatedtompound (PFC) exposure with metabolic interruption, but the inter-species difference and high treatment doses usually make the results difficult to be extrapolated to humans directly. The best strategy for identifying the metabolic interruption may be to establish the direct correlations between monitored PFCs data and metabolic data on human samples. In this study, serum metabolome data and PFC concentrations were acquired for a Chinese adult male cohort. The most abundant PFCs are PFOA and PFOS with concentration medians 7.56 and 12.78 nM, respectively; in together they count around 81.6% of the total PFCs. PFC concentration-related serum metabolic profile changes and the related metabolic biomarkers were explored by using partial least squares-discriminant analysis (PLS-DA). Respectively taking PFOS, PFOA and total PFC as the classifiers, serum metabolome can be differentiated between the lowest dose group (1st quartile PFCs) and the highest PFC dose group (4th quartile PFCs). Ten potential PFC biomarkers were identified, mainly involving in pollutant detoxification, antioxidation and nitric oxide (NO) signal pathways. These suggested that low-level environmental PFC exposure has significantly adverse impacts on glutathione (GSH) cycle, Krebs cycle, nitric oxide (NO) generation and purine oxidation in humans. To the best of our knowledge, this is the first report investigating the association of environmental PFC exposure with human serum metabolome alteration. Given the important biological functions of the identified biomarkers, we suggest that PFC could increase the metabolism syndromes risk including diabetes and cardiovascular diseases. (C) 2017 Elsevier Ltd. All rights reserved.